ArticleDevelopment (Cambridge, England)2014
Pitx2c ensures habenular asymmetry by restricting parapineal cell number.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior.Journal of pineal research · 2022Article
- Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel.Frontiers in cell and developmental biology · 2022Article
- Conserved and diverged asymmetric gene expression in the brain of teleosts.Frontiers in cell and developmental biology · 2022Article
- Pitx controls amphioxus asymmetric morphogenesis by promoting left-side development and repressing right-side formation.BMC biology · 2021Article
- Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders.Biomolecules · 2021Review
- Brain and Behavioral Asymmetry: A Lesson From Fish.Frontiers in neuroanatomy · 2020Review
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- Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications.Scientific reports · 2018Article
- Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs.Developmental biology · 2016Article
- A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex.Development (Cambridge, England) · 2016Article
- The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain.Nature communications · 2015Article
- Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons.Current biology : CB · 2014Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. Morphological symmetry in the epithalamus is broken by leftward migration of the parapineal, which is required for the subsequent elaboration of left habenular identity; the habenular nuclei flank the midline and show L/R asymmetries in marker expression and connectivity. The Nodal target pitx2c is expressed in the left epithalamus, but nothing is known about its role during the establishment of asymmetry in the brain. We show that abrogating Pitx2c function leads to the right habenula adopting aspects of left character, and to an increase in parapineal cell numbers. Parapineal ablation in Pitx2c loss of function results in right habenular isomerism, indicating that the parapineal is required for the left character detected in the right habenula in this context. Partial parapineal ablation in the absence of Pitx2c, however, reduces the number of parapineal cells to wild-type levels and restores habenular asymmetry. We provide evidence suggesting that antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.