ArticleNano letters2014
Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies.
Article in Nano letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Next-Generation Hydrogel Design: Computational Advances in Synthesis, Characterization, and Biomedical Applications.Polymers · 2025Review
- 3D and 4D assembly of functional structures using shape-morphing materials for biological applications.Frontiers in bioengineering and biotechnology · 2024Review
- Mechanically-Guided 3D Assembly for Architected Flexible Electronics.Chemical reviews · 2023Review
- Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity.Signal transduction and targeted therapy · 2021Review
- Wavefront Control with Nanohole Array-Based Out-of-Plane Metasurfaces.ACS applied nano materials · 2021Article
- Kirigami/origami: unfolding the new regime of advanced 3D microfabrication/nanofabrication with "folding".Light, science & applications · 2020Review
- Mechanosensing of Mechanical Confinement by Mesenchymal-Like Cells.Frontiers in physiology · 2020Review
- Connections between the cell cycle, cell adhesion and the cytoskeleton.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- On-Demand Intracellular Delivery of Single Particles in Single Cells by 3D Hollow Nanoelectrodes.Nano letters · 2019Article
- Origami Biosystems: 3D Assembly Methods for Biomedical Applications.Advanced biosystems · 2018Review
- Cell Assembly in Self-foldable Multi-layered Soft Micro-rolls.Scientific reports · 2017Article
- Interface Adhesion and Structural Characterization of Rolled-up GaAs/InScientific reports · 2017Article
- Three-Dimensional Multiscale, Multistable, and Geometrically Diverse Microstructures with Tunable Vibrational Dynamics Assembled by Compressive Buckling.Advanced functional materials · 2017Article
- Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation.Advanced healthcare materials · 2016Article
- Molecular Insights into Division of Single Human Cancer Cells in On-Chip Transparent Microtubes.ACS nano · 2016Article
- A Self-Folding Hydrogel In Vitro Model for Ductal Carcinoma.Tissue engineering. Part C, Methods · 2016Article
- Patterning of Fibroblast and Matrix Anisotropy within 3D Confinement is Driven by the Cytoskeleton.Advanced healthcare materials · 2016Article
- Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism.Nano letters · 2015Article
- Confinement and deformation of single cells and their nuclei inside size-adapted microtubes.Advanced healthcare materials · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We use micropatterning and strain engineering to encapsulate single living mammalian cells into transparent tubular architectures consisting of three-dimensional (3D) rolled-up nanomembranes. By using optical microscopy, we demonstrate that these structures are suitable for the scrutiny of cellular dynamics within confined 3D-microenvironments. We show that spatial confinement of mitotic mammalian cells inside tubular architectures can perturb metaphase plate formation, delay mitotic progression, and cause chromosomal instability in both a transformed and nontransformed human cell line. These findings could provide important clues into how spatial constraints dictate cellular behavior and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.