Trial reportDiabetic medicine : a journal of the British Diabetic Association2014
Post-partum weight loss and glucose metabolism in women with gestational diabetes: the DEBI Study.
Trial report in Diabetic medicine : a journal of the British Diabetic Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Barriers to and enablers of postpartum health behaviours among women from diverse cultural backgrounds with prior gestational diabetes: A systematic review and qualitative synthesis applying the theoretical domains framework.Diabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- Diabetes after pregnancy prevention trials: Systematic review for core outcome set development.Maternal & child nutrition · 2020Pooled it
- Lifestyle interventions for the treatment of women with gestational diabetes.The Cochrane database of systematic reviews · 2017Pooled it
- Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes.Scientific reports · 2021Trial
- Mothers after Gestational Diabetes in Australia (MAGDA): A Randomised Controlled Trial of a Postnatal Diabetes Prevention Program.PLoS medicine · 2016Trial
- Postpartum Glucose Intolerance in Women with a History of Gestational Diabetes Mellitus: An In-Depth Review.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- Comparative differences in metabolic, mental health and perinatal outcomes of women with gestational diabetes in Ghana and Switzerland: the G-MUM study.BMC pregnancy and childbirth · 2025Observational
- Lifestyle interventions in later reproductive age women to offset cardiometabolic and bone disease: a scoping review.Nutrition & metabolism · 2025Review
- Effectiveness of the Information-Motivation-Behavioral Skills Model-Based Nursing Intervention on Maternal and Neonatal Outcomes in Women with Gestational Diabetes Mellitus: A Randomized Controlled Trial.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Perspectives of stakeholders on the implementation of a dietary and exercise intervention for postpartum mothers with a history of gestational diabetes mellitus (GDM): a community-based qualitative study.Scientific reports · 2024Article
- Impact of postpartum weight change on metabolic syndrome and its components among women with recent gestational diabetes mellitus.Reproductive health · 2024Article
- Clinical and Metabolic Characterization of Women With Gestational Diabetes Mellitus Within the First Year Postpartum.Journal of the Endocrine Society · 2024Article
- Evidence and consensus-based clinical practice guideline for the management of obesity and overweight in postpartum women: An AIIMS-DST initiative.Journal of family medicine and primary care · 2023Review
- Pregnancy Complications Can Foreshadow Future Disease-Long-Term Outcomes of a Complicated Pregnancy.Medicina (Kaunas, Lithuania) · 2021Review
- Specific amino acids but not total protein attenuate postpartum weight gain among Hispanic women from Southern California.Food science & nutrition · 2021Article
- Translating Research on Diabetes and Obesity in Pregnancy Into Prevention: The 2019 Norbert Freinkel Award Lecture.Diabetes care · 2020Article
- Added sugar and sugar-sweetened beverages are associated with increased postpartum weight gain and soluble fiber intake is associated with postpartum weight loss in Hispanic women from Southern California.The American journal of clinical nutrition · 2020Article
- Study protocol: Using peer support to aid in prevention and treatment in prediabetes (UPSTART).Contemporary clinical trials · 2020Article
- Early life environment influences the trajectory of post-partum weight loss in adult female rats.Reproductive biomedicine online · 2019Article
- Protocol for a two-arm feasibility RCT to support postnatal maternal weight management and positive lifestyle behaviour in women from an ethnically diverse inner city population: the SWAN feasibility trial.Pilot and feasibility studies · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
aimsWomen with gestational diabetes are at high risk for developing diabetes; post-partum weight loss may reduce the risk of diabetes. We evaluated the association of post-partum weight change with changes in glucose, insulin and homeostasis model assessment of insulin resistance in a subsample (n = 72) of participants from Diet Exercise and Breastfeeding Intervention (DEBI), a randomized pilot trial of lifestyle intervention for women with gestational diabetes.
methodsGlucose and insulin were measured fasting and 2 h after an oral glucose tolerance test at 6 weeks and 12 months post-partum. Women were categorized by weight change (lost > 2 kg vs. maintained/gained) between 6 weeks and 12 months post-partum.
resultsCompared with women who maintained or gained weight, women who lost > 2 kg experienced significantly lower increases in fasting glucose [age-adjusted means: 0.1 mmol/l (95% CI -0.03 to 0.3) vs. 0.4 mmol/l (95% CI 0.3-0.6); P < 0.01] and 2-h insulin [10.0 pmol/l (95% CI -56.9 to 76.9) vs. 181.2 pmol/l (95% CI 108.3-506.9); P < 0.01] and a significant reduction in 2-h glucose [-0.9 mmol/l (95% CI -1.4 to -0.3) vs. 0.3 mmol/l (95% CI -0.3 to 0.9); P < 0.01]. In multiple linear regression models adjusted for age, Hispanic ethnicity, medication use, meeting the Institute of Medicine's recommendations for gestational weight gain, breastfeeding and randomized group, a 1-kg increase in weight was significantly associated with increases in fasting and 2-h glucose (P < 0.05), but was not associated with insulin or homeostasis model assessment of insulin resistance.
conclusionsIn women with gestational diabetes, modest post-partum weight loss may be associated with improvements in glucose metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.