ArticleBMC veterinary research2014
Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs.
Article in BMC veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience.GeroScience · 2025Article
- Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs.Scientific reports · 2025Article
- (Un)Tying the Knot: Oxidative Stress, Inflammatory Markers, and Lipid Status in Dogs with Hypercortisolism.Animals : an open access journal from MDPI · 2024Article
- Hematological and biochemical parameters in the blood of working Belgian Shepherd dogs: An age-related study.Open veterinary journal · 2024Article
- Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs.Animals : an open access journal from MDPI · 2024Article
- Lipoprotein profiles in Miniature Schnauzer dogs with idiopathic hypertriglyceridemia and hypercortisolism.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Sequence Analysis of Six Candidate Genes in Miniature Schnauzers with Primary Hypertriglyceridemia.Genes · 2024Article
- Serum Bile Acids Concentrations and Liver Enzyme Activities after Low-Dose Trilostane in Dogs with Hyperadrenocorticism.Animals : an open access journal from MDPI · 2023Article
- Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1.Frontiers in veterinary science · 2023Article
- Acute phase protein response and changes in lipoprotein particle size in dogs with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2022Article
- Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience.Frontiers in veterinary science · 2022Article
- Changes in Serum Lipid Profiles among Canine Patients Suffering from Chronic Hepatitis.Veterinary sciences · 2021Article
- Alterations of Lipid Metabolism With Age and Weight in Companion Dogs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Relationships between expression levels of genes related to adipogenesis and adipocyte function in dogs.Molecular biology reports · 2019Article
- Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs.Journal of veterinary internal medicine · 2019Article
- Clinical Consequences of Hypertriglyceridemia-Associated Proteinuria in Miniature Schnauzers.Journal of veterinary internal medicine · 2017Article
- Aging effect on plasma metabolites and hormones concentrations in riding horses.Open veterinary journal · 2015Article
- The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs.BMC research notes · 2014Article
- Serum lipoprotein changes in dogs with renal disease.Journal of veterinary internal medicineArticle
- Clustering analysis of lipoprotein profiles to identify subtypes of hypertriglyceridemia in Miniature Schnauzers.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. In this study, we investigated the changes in plasma cholesterol and triglyceride (TG) profiles and metabolite concentrations in 24 dogs (young group: 0-7 years old, n = 12, aged group: 8-13 years old, n = 12).
resultsPlasma adiponectin (ADN) concentrations were significantly lower in aged dogs than those in young dogs (mean ± SD, 17.2 ± 10.0 μg mL-1 vs 29.3 ± 12.5 μg mL-1, respectively; P <0.05). Although there were no significant differences statistically, aged dogs showed significantly higher plasma alpha1- acid glycoprotein (alpah1-AG) levels compared to those in young dogs. Plasma cholesterol lipoprotein and TG lipoprotein were divided into four fractions by biphasic agarose gel electrophoresis technique. The levels of the third TG-lipoprotein fraction from the positive pole (TG Fraction 3) were significantly higher in aged dogs than in young dogs (mean ± SD, 143.0 ± 109.3 mg dL-1 vs 55.2 ± 31.3 mg dL-1, respectively; P <0.05). On the correlation coefficient analysis by Peason's method, moderate positive correlations were seen between the age and TG (r = 0.446, P = 0.029), TG Fraction 3 (r = 0.516, P = 0.010), malondialdehyde (r = 0.146, P = 0.043), alpha-1 AG (r = 0.448, P = 0.028) levels, respectively. Moderate negative correlations were seen the age and total cholesterol (TC) Fraction 2 (r = -0.446, P = 0.029), glucose (r = -0.637, P = 0.001), ADN (r = -0.408, P = 0.048), respectively.
conclusionsPresent data suggest biochemical characteristics of lipid metabolism disorder may be affected by aging in dogs.
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