Evidence map›Paper›PMID 24597611›Full record

ArticleThe Journal of organic chemistry2014

Ribonucleosides for an artificially expanded genetic information system.

Hyo-Joong Kim, Nicole A Leal, Shuichi Hoshika, Steven A Benner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Overcoming Challenges in Engineering the Genetic Code.Journal of molecular biology · 2016
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hyo-Joong KimFoundation for Applied Molecular Evolution (FfAME), 720 SW Second Avenue, Suite 201, Gainesville, Florida 32601, United States.
Nicole A Leal
Shuichi Hoshika
Steven A Benner

Funding

Improved HIV Assays by Combining Four Innovations in Nucleic Acid ChemistryR01AI098616 · NIAID · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · PI BENNER, STEVEN A · 2012 to 2014
$1.1M
NIAID NIH HHS R01 AI098616NIAID NIH HHS R01AI098616
6 · The paper itself

Abstract

Rearranging hydrogen bonding groups adds nucleobases to an artificially expanded genetic information system (AEGIS), pairing orthogonally to standard nucleotides. We report here a large-scale synthesis of the AEGIS nucleotide carrying 2-amino-3-nitropyridin-6-one (trivially Z) via Heck coupling and a hydroboration/oxidation sequence. RiboZ is more stable against epimerization than its 2'-deoxyribo analogue. Further, T7 RNA polymerase incorporates ZTP opposite its Watson-Crick complement, imidazo[1,2-a]-1,3,5-triazin-4(8H)one (trivially P), laying grounds for using this "second-generation" AEGIS Z:P pair to add amino acids encoded by mRNA.

Indexed as

Amino AcidsBase PairingBorohydridesDNA-Directed RNA PolymerasesHydrogen BondingImidazolesNucleosidesNucleotidesPyridinesRibonucleosidesRNA, MessengerTriazinesViral Proteins2-amino-3-nitropyridin-6-oneAmino Acidsbacteriophage T7 RNA polymeraseBorohydridesDNA-Directed RNA Polymerasesimidazo(1,2-a)-1,3,5-triazin-4(8H)oneImidazolesNucleosidesNucleotidesPyridinesRibonucleosidesRNA, MessengerTriazinesViral Proteins

Identifiers

PMID24597611
PMCPMC3985877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.