ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2014
Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Biomarkers of Hepatic Toxicity: An Overview.Current therapeutic research, clinical and experimental · 2024Review
- Article
- Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.Nature communications · 2023Article
- Therapeutic effects of mesenchymal stem cells-conditioned medium derived from suspension cultivation or silymarin on liver failure mice.Molecular biology reports · 2022Article
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Plasma Concentration of Taurine Changes following Acetaminophen Overdose in Male Patients during Hospitalization.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019Article
- Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.Expert review of molecular diagnostics · 2018Review
- Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives.Journal of clinical and translational research · 2018Review
- Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Journal of clinical and translational research · 2017Article
- The past and present of serum aminotransferases and the future of liver injury biomarkers.EXCLI journal · 2016Review
- Translational biomarkers of acetaminophen-induced acute liver injury.Archives of toxicology · 2015Review
- Inflammasome activation and function in liver disease.Nature reviews. Gastroenterology & hepatology · 2015Review
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.Toxicology and applied pharmacology · 2015Article
- Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.Digestive diseases (Basel, Switzerland) · 2015Review
- Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Toxicology and applied pharmacology · 2014Article
- Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.Expert opinion on drug metabolism & toxicology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
contextNew biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate.
objectiveCharacterize ASS in APAP hepatotoxicity.
methodsASS was measured in plasma from rodents and humans with APAP hepatotoxicity.
resultsIn mice, ASS increased before injury, peaked before alanine aminotransferase (ALT) and decreased rapidly. Fischer rats had a greater increase in ASS relative to ALT. Patients with abnormal liver test results had very high ASS compared to controls. ASS appeared to increase early in some patients, and declined rapidly in all.
conclusionsASS may be a useful biomarker of acute cell death in APAP hepatotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.