ArticleBiomacromolecules2014
Interaction of hyaluronan binding peptides with glycosaminoglycans in poly(ethylene glycol) hydrogels.
Article in Biomacromolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Biomimetic Hyaluronan Binding Biomaterials to Capture the Complex Regulation of Hyaluronan in Tissue Development and Function.Biomimetics (Basel, Switzerland) · 2024Review
- Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing.Cold Spring Harbor perspectives in biology · 2023Review
- Atomic-Resolution Experimental Structural Biology and Molecular Dynamics Simulations of Hyaluronan and Its Complexes.Molecules (Basel, Switzerland) · 2022Review
- One-pot synthesis of hyaluronic acid-coated gold nanoparticles as SERS substrate for the determination of hyaluronidase activity.Mikrochimica acta · 2020Article
- A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy.Bioengineering (Basel, Switzerland) · 2019Article
- Review
- A MMP7-sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage.Journal of biomedical materials research. Part A · 2018Article
- Functional peptides for cartilage repair and regeneration.American journal of translational research · 2018Article
- Hyaluronan-binding peptide for targeting peritoneal carcinomatosis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2017Article
- Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells.Biomaterials · 2016Article
- Harnessing the Versatility of Bacterial Collagen to Improve the Chondrogenic Potential of Porous Collagen Scaffolds.Advanced healthcare materials · 2016Article
- Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration.Biomaterials · 2015Article
- Thiol-norbornene photo-click hydrogels for tissue engineering applications.Journal of applied polymer science · 2015Article
- Concise review: tailoring bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine.Stem cells translational medicine · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This study investigates the incorporation of hyaluronan (HA) binding peptides into poly(ethylene glycol) (PEG) hydrogels as a mechanism to bind and retain hyaluronan for applications in tissue engineering. The specificity of the peptide sequence (native RYPISRPRKRC vs non-native RPSRPRIRYKC), the role of basic amino acids, and specificity to hyaluronan over other GAGs in contributing to the peptide-hyaluronan interaction were probed through experiments and simulations. Hydrogels containing the native or non-native peptide retained hyaluronan in a dose-dependent manner. Ionic interactions were the dominating mechanism. In diH2O the peptides interacted strongly with HA and chondroitin sulfate, but in phosphate buffered saline the peptides interacted more strongly with HA. For cartilage tissue engineering, chondrocyte-laden PEG hydrogels containing increasing amounts of HA binding peptide and exogenous HA had increased retention and decreased loss of cell-secreted proteoglycans in and from the hydrogel at 28 days. This new matrix-interactive hydrogel platform holds promise for tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.