Trial reportBMC psychiatry2014
The effectiveness of integrated treatment in patients with substance use disorders co-occurring with anxiety and/or depression--a group randomized trial.
Trial report in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00447733 (Effects of Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders.Journal of substance use and addiction treatment · 2024Pooled it
- Evaluating the effects of tDCS on depressive and anxiety symptoms from a transdiagnostic perspective: a systematic review and meta-analysis of randomized controlled trials.Translational psychiatry · 2024Pooled it
- Psychological interventions for co-occurring depression and substance use disorders.The Cochrane database of systematic reviews · 2019Pooled it
- Association Between Integrated Treatment Services and Access to Detoxification and MOUD Across US Treatment Facilities.The journal of behavioral health services & research · 2026Article
- Review
- Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment.Frontiers in psychiatry · 2026Article
- Designing a Nurse-Led Program for Self-Management of Substance Addiction Consequences: A Modified e-Delphi Study.International journal of environmental research and public health · 2023Article
- Integrated vs non-integrated treatment outcomes in dual diagnosis disorders: A systematic review.Health SA = SA Gesondheid · 2023Article
- Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals.Scientific reports · 2021Article
- Enhancing prevention and intervention for youth concurrent mental health and substance use disorders: The Research and Action for Teens study.Early intervention in psychiatry · 2019Article
- The role of substance use coping in the relation between childhood sexual abuse and depression among methamphetamine users in South Africa.Psychological trauma : theory, research, practice and policy · 2017Article
- Interventions for Subjects with Depressive Symptoms with or without Unhealthy Alcohol Use: Are There Different Patterns of Change?Frontiers in psychology · 2017Article
- Stress Management and Relaxation Techniques use among underserved inpatients in an inner city hospital.Complementary therapies in medicine · 2015Article
- Comorbid Psychopathology and Alcohol Use Patterns among Methadone Maintenance Treatment Patients.Journal of addiction · 2015Article
- Abuse and misuse of antidepressants.Substance abuse and rehabilitation · 2014Review
- Motivation for treatment in patients with substance use disorder: personal volunteering versus legal/familial enforcement.Neuropsychiatric disease and treatment · 2014Article
- Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntegrated Treatment (IT) has proved effective in treating patients with Substance Use Disorders (SUD) co-occurring with severe Mental Disorders (MD), less is known about the effectiveness of IT for patients with SUD co-occurring with less severe MD.The aim of this study was to investigate the effectiveness of IT for patients with SUD co-occurring with anxiety and/or depression on the following parameters:1. The use of substances, as measured by the Alcohol Use Identification Test (AUDIT), the Drug Use Identification Test (DUDIT), and the Addiction Severity Index (EuropASI).2. The severity of psychiatric symptoms, as measured by the Symptom Check List 90 r (SCL 90R).3. The client's motivation for changing his/her substance use behaviour, as measured by the Substance Abuse Treatment Scale (SATSr).
methodsThis is a group randomized clinical trial comparing the effectiveness of IT to treatment as usual in Community Mental Health Centres (CMHCs). Five CMHCs were drawn to the Intervention Group (IG) and four CMHCs to the Control Group (CG). The allocation to treatment conditions was not blinded. New referrals were screened with the AUDIT and the DUDIT. Those who scored above the cut-off level of these instruments were assessed with the Structured Clinical Interview for DSM-IV 1 and 2. We included patients with anxiety and/or depression together with one or more SUDs.
resultsWe included 55 patients in the IG and 21 in the CG. A linear multilevel model was used. Both groups reduced their alcohol and substance use during the trial, while there was no change in psychiatric symptoms in either group. However, the IG had a greater increase in motivation for substance use treatment after 12 months than had the CG with an estimate of 1.76, p = 0.043, CI95% (0.08; 3.44) (adjusted analyses). There were no adverse events.
conclusionsIntegrated treatment is effective in increasing the motivation for treatment amongst patients with anxiety and/or depression together with SUD in outpatient clinics.
trial registrationClinicalTrials.gov: NCT00447733.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.