Extreme hyperleukocytosis in a pediatric T-ALL patient with a rare translocation, t(7;19)(q35;p13), and submicroscopic deletions at 4q25, 7q33 and 10q23.

Christopher Veigaard, Anni Aggerholm, Henrik Hasle, Eigil Kjeldsen

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Article in Leukemia research reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 88% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Chronic Myeloid Leukemia Presenting With T-Lymphoid Blast Crisis in a Young Female With Marked Hyperleukocytosis: A Case Report.EJHaem · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher VeigaardHemodiagnostic Laboratory, Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, Ent. 4A, 8000 Aarhus C, Denmark.

Anni AggerholmHemodiagnostic Laboratory, Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, Ent. 4A, 8000 Aarhus C, Denmark.

Henrik HasleDepartment of Pediatrics, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark.

Eigil KjeldsenHemodiagnostic Laboratory, Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, Ent. 4A, 8000 Aarhus C, Denmark.

Aarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although childhood T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk disease the outcome can vary considerably. The varying outcomes suggest that unrecognized factors may contribute to disease progression. We report on a 2-year-old T-ALL patient presenting with a very short history of constipation and extreme hyperleukocytosis (WBC 882×10(9)/L). In her leukemic cells we detected the very rare translocation t(7;19)(q35;p13) and LYL1 overexpression. Additionally, we detected submicroscopic deletions at 4q25, 7q33 and 10q23 by oligo-aCGH analysis. We suggest that LYL1 overexpression contributed to the leukemic state and propose that the observed microdeletions may have influenced to the rapid disease progression.

Indexed as

aCGH analysisAcute T-lymphoblastic leukemiaHyperleukocytosisLYL1t(7;19)

Identifiers

PMID24596673

DOI10.1016/j.lrr.2013.09.004

PMCPMC3939383

OpenAlexW1989878858

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.