Evidence map›Paper›PMID 24596666›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2014

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.

Dina le Roux, Pieter B Burger, Jandeli Niemand, Anne Grobler, Patricia Urbán, Xavier Fernàndez-Busquets, Robert H Barker, Adelfa E Serrano, Abraham I Louw, Lyn-Marie Birkholtz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Antibacterial Activity of Aureonuclemycin Produced byMolecules (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Dina le RouxDepartment of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Pieter B BurgerDepartment of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Jandeli NiemandDepartment of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Anne GroblerDST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom 2531, South Africa.
Patricia UrbánNanobioengineering Group, Institute for Bioengineering of Catalonia, Baldiri Reixac 10-12, Barcelona E08028, Spain ; Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Rosselló 149-153, Barcelona E08036, Spain ; Biomolecular Interactions Team, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, Barcelona E08028, Spain.
Xavier Fernàndez-BusquetsNanobioengineering Group, Institute for Bioengineering of Catalonia, Baldiri Reixac 10-12, Barcelona E08028, Spain ; Barcelona Centre for International Health Research (CRESIB), Hospital Clínic-Universitat de Barcelona, Rosselló 149-153, Barcelona E08036, Spain ; Biomolecular Interactions Team, Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, Barcelona E08028, Spain.
Robert H BarkerGenzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA.
Adelfa E SerranoUniversity of Puerto Rico-School of Medicine, Department of Microbiology and Medical Zoology, P.O. Box 365067, San Juan PR 00936-5067, Puerto Rico.
Abraham I LouwDepartment of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
Lyn-Marie BirkholtzDepartment of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa.
University of Pretoria · ZAInstitute for Bioengineering of Catalonia · ESNorth-West University · ZAUniversitat de Barcelona · ESUniversity of Puerto Rico, Medical Sciences Campus · PR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

S-adenosyl-l-methionine decarboxylase (AdoMetDC) in the polyamine biosynthesis pathway has been identified as a suitable drug target in Plasmodium falciparum parasites, which causes the most lethal form of malaria. Derivatives of an irreversible inhibitor of this enzyme, 5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine (MDL73811), have been developed with improved pharmacokinetic profiles and activity against related parasites, Trypanosoma brucei. Here, these derivatives were assayed for inhibition of AdoMetDC from P. falciparum parasites and the methylated derivative, 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]methylamino}-5'-deoxyadenosine (Genz-644131) was shown to be the most active. The in vitro efficacy of Genz-644131 was markedly increased by nanoencapsulation in immunoliposomes, which specifically targeted intraerythrocytic P. falciparum parasites.

Indexed as

AdoMetDC, S-adenosyl-l-methionine decarboxylaseAdoMet, S-adenosyl-l-methioninedcAdoMet, decarboxylated S-adenosyl-l-methionineDFMO, dl-α-difluoromethylornithineGenz-644043, 2′-fluoro-5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosineGenz-644053, 2-chloro-5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosineGenz-644131, 8-methyl-5′-{[(Z)-4-aminobut-2-enyl]methylamino}-5′-deoxyadenosineImmunoliposomesMDL73811, 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosineODC, ornithine decarboxylasePlasmodiumPolyaminesS-adenosyl-l-methionine decarboxylase

Identifiers

PMID24596666
PMCPMC3940083
OpenAlexW2082347667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.