Evidence map›Paper›PMID 24596594›Full record

ArticleInternational journal of molecular epidemiology and genetics2014

Gene expression in thiazide diuretic or statin users in relation to incident type 2 diabetes.

Astrid Suchy-Dicey, Susan R Heckbert, Nicholas L Smith, Barbara McKnight, Jerome I Rotter, Yd Ida Chen, Bruce M Psaty, Daniel A Enquobahrie

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of molecular epidemiology and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Astrid Suchy-DiceyDepartment of Epidemiology, University of Washington Seattle, WA, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington Seattle, WA, USA ; Department of Pharmacy, University of Washington Seattle, WA, USA ; Group Health Research Institute, Group Health Cooperative Seattle, WA, USA.
Nicholas L SmithDepartment of Epidemiology, University of Washington Seattle, WA, USA ; Group Health Research Institute, Group Health Cooperative Seattle, WA, USA ; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development Seattle, WA, USA.
Barbara McKnightDepartment of Biostatistics, University of Washington Seattle, WA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center Torrance, CA, USA.
Yd Ida ChenInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center Torrance, CA, USA.
Bruce M PsatyDepartment of Epidemiology, University of Washington Seattle, WA, USA ; Department of Health Services, University of Washington Seattle, WA, USA ; Department of Medicine, University of Washington Seattle, WA, USA ; Group Health Research Institute, Group Health Cooperative Seattle, WA, USA.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington Seattle, WA, USA.
University of Washington · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal womenR01HL073410 · NHLBI · UNIVERSITY OF WASHINGTON · PI SMITH, NICHOLAS L · 2004 to 2012
$4.8M
CVD Epidemiology Training ProgramT32HL007902 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1998 to 2012
$3.6M
Atrial Fibrillation: Incidence, Risk Factors, and GeneticsR01HL068986 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2002 to 2010
$3.5M
Pharmacogenetics and Cardiovascular EventsR01HL074745 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2003 to 2006
$2.8M
Hormone Replacement Therapy and Prothrombotic VariantsR01HL068639 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2002 to 2005
$1.9M
NCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL068639NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL074745NHLBI NIH HHS T32 HL007902NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

Thiazide diuretics and statins are used to improve cardiovascular outcomes, but may also cause type 2 diabetes (T2DM), although mechanisms are unknown. Gene expression studies may facilitate understanding of these associations. Participants from ongoing population-based studies were sampled for these longitudinal studies of peripheral blood microarray gene expression, and followed to incident diabetes. All sampled subjects were statin or thiazide users. Those who developed diabetes during follow-up comprised cases (44 thiazide users; 19 statin users), and were matched to drug-using controls who did not develop diabetes on several factors. Supervised normalization, surrogate variable analyses removed technical bias and confounding. Differentially-expressed genes were those with a false discovery rate Q-value<0.05. Among thiazide users, diabetes cases had significantly different expression of CCL14 (down-regulated 6%, Q-value=0.0257), compared with controls. Among statin users, diabetes cases had marginal but insignificantly different expression of ZNF532 (up-regulated 15%, Q-value=0.0584), CXORF21 (up-regulated 11%, Q-value=0.0584), and ZNHIT3 (up-regulated 19%, Q-value=0.0959), compared with controls. These genes comprise potential targets for future expression or mechanistic research on medication-related diabetes development.

Indexed as

chemokine ligand 14gene expressionmicroarraystatinssupervised normalizationsurrogate variable analysisthiazide diureticsType 2 diabeteswhole bloodzinc finger proteins

Identifiers

PMID24596594
PMCPMC3939004
OpenAlexW1756880171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.