ReviewFrontiers in endocrinology2014
Gene-environment interactions and intermediate phenotypes: early trauma and depression.
Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Nutrients and Functional Components of Medicine and Food Homology Substances on Antidepressant Effects: A Mechanism-Oriented Review.Molecules (Basel, Switzerland) · 2026Review
- A genetic study of immunity in depression and interactions with childhood maltreatment.Translational psychiatry · 2026Article
- Article
- Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders.Neuropharmacology · 2021Review
- Influence ofFrontiers in behavioral neuroscience · 2021Article
- Association between childhood trauma and brain anatomy in women with post-traumatic stress disorder, women with borderline personality disorder, and healthy women.European journal of psychotraumatology · 2021Article
- The roles of comorbidity and trauma exposure and its timing in shaping HPA axis patterns in depression.Psychoneuroendocrinology · 2020Article
- Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms.Journal of psychiatric research · 2020Article
- Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation.Current genomics · 2018Review
- Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health.Neuroscience and biobehavioral reviews · 2018Review
- Article
- Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?Human genomics · 2017Review
- DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation.Journal of psychiatric research · 2017Article
- Childhood neglect predicts the course of major depression in a tertiary care sample: a follow-up study.BMC psychiatry · 2017Article
- Childhood adversity and midlife suicidal ideation.Psychological medicine · 2017Article
- Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation.Physiology & behavior · 2015Article
- Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: implications for differential susceptibility.Development and psychopathology · 2015Article
- Interactions between the apolipoprotein E ε4 allele status and adverse childhood experiences on depressive symptoms in older adults.European journal of psychotraumatology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review focuses on current research developments in the study of gene by early life stress (ELS) interactions and depression. ELS refers to aversive experiences during childhood and adolescence such as sexual, physical or emotional abuse, emotional or physical neglect as well as parental loss. Previous research has focused on investigating and characterizing the specific role of ELS within the pathogenesis of depression and linking these findings to neurobiological changes of the brain, especially the stress response system. The latest findings highlight the role of genetic factors that increase vulnerability or, likewise, promote resilience to depression after childhood trauma. Considering intermediate phenotypes has further increased our understanding of the complex relationship between early trauma and depression. Recent findings with regard to epigenetic changes resulting from adverse environmental events during childhood promote current endeavors to identify specific target areas for prevention and treatment schemes regarding the long-term impact of ELS. Taken together, the latest research findings have underscored the essential role of genotypes and epigenetic processes within the development of depression after childhood trauma, thereby building the basis for future research and clinical interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.