ArticleInternational journal of nanomedicine2014
Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Trial
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- Article
- Short-Term Intravenous Administration of Carbon Nano-Onions is Non-Toxic in Female Mice.International journal of nanomedicine · 2023Article
- PMToxicology research · 2019Article
- The neurotoxicity induced by engineered nanomaterials.International journal of nanomedicine · 2019Review
- Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers.International journal of nanomedicine · 2019Review
- Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity ofJournal of traditional and complementary medicine · 2018Article
- Prenatal Exposure to DEHP Induces Neuronal Degeneration and Neurobehavioral Abnormalities in Adult Male Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- A smart multi-functional coating based on anti-pathogen micelles tethered with copper nanoparticlesRSC advances · 2018Article
- Recent Advances in the Therapeutic and Diagnostic Use of Liposomes and Carbon Nanomaterials in Ischemic Stroke.Frontiers in neuroscience · 2018Review
- At seeming safe concentrations, synergistic effects of PMOncotarget · 2017Article
- Influence of multi-walled carbon nanotubes on the cognitive abilities of Wistar rats.Experimental and therapeutic medicine · 2016Article
- Cognitive deficits and anxiety induced by diisononyl phthalate in mice and the neuroprotective effects of melatonin.Scientific reports · 2015Article
- Carbon nanotubes part II: a remarkable carrier for drug and gene delivery.Expert opinion on drug delivery · 2015Review
- PEGylated carbon nanotubes impair retrieval of contextual fear memory and alter oxidative stress parameters in the rat hippocampus.BioMed research international · 2015Article
- Multi-walled carbon nanotubes increase anxiety levels in rats and reduce exploratory activity in the open field test.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2015Article
- Biopersistence of PEGylated Carbon Nanotubes Promotes a Delayed Antioxidant Response after Infusion into the Rat Hippocampus.PloS one · 2015Article
- Intraperitoneal Injection Is Not a Suitable Administration Route for Single-Walled Carbon Nanotubes in Biomedical Applications.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-walled carbon nanotubes (SWCNTs) have shown increasing promise in the field of biomedicine, especially in applications related to the nervous system. However, there are limited studies available on the neurotoxicity of SWCNTs used in vivo. In this study, neurobehavioral changes caused by SWCNTs in mice and oxidative stress were investigated. The results of ethological analysis (Morris water maze and open-field test), brain histopathological examination, and assessments of oxidative stress (reactive oxygen species [ROS], malondialdehyde [MDA], and glutathione [GSH]), inflammation (nuclear factor κB, tumor necrosis factor α, interleukin-1β), and apoptosis (cysteine-aspartic acid protease 3) in brains showed that 6.25 and 12.50 mg/kg/day SWCNTs in mice could induce cognitive deficits and decreased locomotor activity, brain histopathological alterations, and increased levels of oxidative stress, inflammation, and apoptosis in mouse brains; however, 3.125 mg/kg/day SWCNTs had zero or minor adverse effects in mice, and these effects were blocked by concurrent administration of ascorbic acid. Down-regulation of oxidative stress, inflammation, and apoptosis were proposed to explain the neuroprotective effects of ascorbic acid. This work suggests SWCNTs could induce cognitive deficits and decreased locomotor activity, and provides a strategy to avoid the adverse effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.