ArticleBlood2014
Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Fish and Fish-Based Products for Nutrition and Health in the First 1000 Days: A Systematic Review of the Evidence from Low and Middle-Income Countries.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- Hepcidin is low in children with moderate acute malnutrition and asymptomatic malaria: secondary analysis of a 2×2×3 factorial randomised trial in Burkina Faso.The British journal of nutrition · 2026Trial
- Host iron deficiency protects againstScience advances · 2026Article
- Predictors of anaemia in mothers and children in Uttar Pradesh, India.Public health nutrition · 2024Article
- Effect of small peptide chelated iron on growth performance, immunity and intestinal health in weaned pigs.Porcine health management · 2023Article
- Universal iron supplementation: the best strategy to tackle childhood anaemia in malaria-endemic countries?Wellcome open research · 2023Review
- Clinical characteristics of Plasmodium falciparum infection among symptomatic patients presenting to a major urban military hospital in Cameroon.Malaria journal · 2022Article
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- Malaria is a cause of iron deficiency in African children.Nature medicine · 2021Article
- Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development.Parasite immunology · 2021Review
- Hemoglobin and hepcidin have good validity and utility for diagnosing iron deficiency anemia among pregnant women.European journal of clinical nutrition · 2020Article
- Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children.Wellcome open research · 2020Article
- Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants.Haematologica · 2019Article
- The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women.Haematologica · 2019Article
- The Importance of Iron Status for Young Children in Low- and Middle-Income Countries: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.Science advances · 2019Article
- TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa.International journal of molecular epidemiology and genetics · 2019Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Hepcidin is the master regulatory hormone that governs iron homeostasis and has a role in innate immunity. Although hepcidin has been studied extensively in model systems, there is less information on hepcidin regulation in global health contexts where iron deficiency (ID), anemia, and high infectious burdens (including malaria) all coexist but fluctuate over time. We evaluated iron status, hepcidin levels, and determinants of hepcidin in 2 populations of rural children aged ≤8 years, in the Gambia and Kenya (total n = 848), at the start and end of a malaria season. Regression analyses and structural equation modeling demonstrated, for both populations, similar combinatorial effects of upregulating stimuli (iron stores and to a lesser extent inflammation) and downregulating stimuli (erythropoietic drive) on hepcidin levels. However, malaria season was also a significant factor and was associated with an altered balance of these opposing factors. Consistent with these changes, hepcidin levels were reduced whereas the prevalence of ID was increased at the end of the malaria season. More prevalent ID and lower hepcidin likely reflect an enhanced requirement for iron and an ability to efficiently absorb it at the end of the malaria season. These results, therefore, have implications for ID and malaria control programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.