ArticlePlant physiology2014
Systems analysis of guard cell membrane transport for enhanced stomatal dynamics and water use efficiency.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity.Nature communications · 2026Article
- ALMT12 interacts with and inhibits SLAC1 to modulate stomatal movements and enhance plant biomass.Plant physiology · 2025Article
- Guard cells on the adaxial and abaxial leaf surfaces use different compositions of potassium ion channels to drive light-induced stomatal opening.Nature plants · 2025Article
- A C4 plant K+ channel accelerates stomata to enhance C3 photosynthesis and water use efficiency.Plant physiology · 2025Article
- Article
- Dual function of overexpressing plasma membrane HScience advances · 2024Article
- Speedy stomata of a CPlant, cell & environment · 2024Article
- Stomatal Responses of Two Drought-Tolerant Barley Varieties with Different ROS Regulation Strategies under Drought Conditions.Antioxidants (Basel, Switzerland) · 2023Article
- Drought priming mechanisms in wheat elucidated byFrontiers in plant science · 2023Article
- Engineering a KNature plants · 2022Article
- Editorial: Transport and Membrane Traffic in Stomatal Biology.Frontiers in plant science · 2022Article
- The signatures of organellar calcium.Plant physiology · 2021Review
- Predicting the unexpected in stomatal gas exchange: not just an open-and-shut case.Biochemical Society transactions · 2020Review
- Role of blue and red light in stomatal dynamic behaviour.Journal of experimental botany · 2020Review
- Optimized Protocol for OnGuard2 Software in Studying Guard Cell Membrane Transport and Stomatal Physiology.Frontiers in plant science · 2020Article
- BCL2-ASSOCIATED ATHANOGENE4 Regulates the KAT1 Potassium Channel and Controls Stomatal Movement.Plant physiology · 2019Article
- Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling.PLoS computational biology · 2019Article
- A constraint-relaxation-recovery mechanism for stomatal dynamics.Plant, cell & environment · 2019Article
- Dynamic leaf energy balance: deriving stomatal conductance from thermal imaging in a dynamic environment.Journal of experimental botany · 2019Article
- The Impacts of Fluctuating Light on Crop Performance.Plant physiology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stomatal transpiration is at the center of a crisis in water availability and crop production that is expected to unfold over the next 20 to 30 years. Global water usage has increased 6-fold in the past 100 years, twice as fast as the human population, and is expected to double again before 2030, driven mainly by irrigation and agriculture. Guard cell membrane transport is integral to controlling stomatal aperture and offers important targets for genetic manipulation to improve crop performance. However, its complexity presents a formidable barrier to exploring such possibilities. With few exceptions, mutations that increase water use efficiency commonly have been found to do so with substantial costs to the rate of carbon assimilation, reflecting the trade-off in CO₂ availability with suppressed stomatal transpiration. One approach yet to be explored in detail relies on quantitative systems analysis of the guard cell. Our deep knowledge of transport and homeostasis in these cells gives real substance to the prospect for reverse engineering of stomatal responses, using in silico design in directing genetic manipulation for improved water use and crop yields. Here we address this problem with a focus on stomatal kinetics, taking advantage of the OnGuard software and models of the stomatal guard cell recently developed for exploring stomatal physiology. Our analysis suggests that manipulations of single transporter populations are likely to have unforeseen consequences. Channel gating, especially of the dominant K⁺ channels, appears the most favorable target for experimental manipulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.