ArticleHippocampus2014
Hippocampal output area CA1 broadcasts a generalized novelty signal during an object-place recognition task.
Article in Hippocampus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 117 citations in OpenAlex.
- Hippocampal CA1 gamma power predicts the precision of spatial memory judgments.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Cell-type-specific disruption of nucleus accumbens social representations in a mouse model of autism.Neuron · 2026Article
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- Distinct Hippocampal Mechanisms Support Concept Formation and Updating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distinct contributions of hippocampal pathways in learning regularities and exceptions revealed by functional footprints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
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- Activation patterns in male and female forebrain areas during habituation to food and context novelty.Brain structure & function · 2025Article
- Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism.Scientific reports · 2025Article
- Vector coding and place coding in hippocampus share a common directional signal.Nature communications · 2024Article
- Event boundaries drive norepinephrine release and distinctive neural representations of space in the rodent hippocampus.bioRxiv : the preprint server for biology · 2024Article
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- Recruitment of hippocampal and thalamic pathways to the central amygdala in the control of feeding behavior under novelty.Brain structure & function · 2024Article
- Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.Neuron · 2023Article
- Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion.bioRxiv : the preprint server for biology · 2023Article
- Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.Molecular brain · 2023Article
- Recruitment of Hippocampal and Thalamic Pathways to the Central Amygdala in the Control of Feeding Behavior Under Novelty.Research square · 2023Article
- Development of human hippocampal subfield microstructure and relation to associative inference.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- TRPC4 Channel Knockdown in the Hippocampal CA1 Region Impairs Modulation of Beta Oscillations in Novel Context.Biology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Animals display an innate preference for novelty, spending more time exploring both novel objects and familiar objects in novel locations. This increase in exploration is thought to allow the animal to gather the information necessary to encode new experiences. Despite extensive evidence that increased exploration following spatial change requires the hippocampus, the pattern of hippocampal activity that supports this behavior remains unknown. We examined activity in hippocampal output area CA1 and one synapse upstream in area CA3 while freely behaving rats performed an object-place recognition task. We found that the presence of novelty substantially altered activity in CA1, but not in CA3. During exploration of displaced familiar objects and novel objects in unexpected locations, CA1 place cells showed robust increases in firing rate. These firing rate increases persisted during sharp wave ripples, when place cell representations of previous experiences are replayed. Unexpectedly, increases in CA1 activity were not spatially restricted to regions of the environment that underwent change, indicating a generalized novelty signal. We suggest that hippocampal area CA1 broadcasts the presence of novelty, rather than signaling what is novel, and simultaneously becomes more plastic, allowing the integration of new information into previously stored memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.