Evidence map›Paper›PMID 24596132›Full record

ArticleAngewandte Chemie (International ed. in English)2014

Divergent total syntheses of lyconadins A and C.

Yang Yang, Christopher W Haskins, Wandi Zhang, Pui Leng Low, Mingji Dai

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Advancing Total Synthesis Through Skeletal Editing.Accounts of chemical research · 2025
    Article
  3. Total Syntheses of Hosieines A-C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  4. Article
  5. Article
  6. Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A.Journal of the American Chemical Society · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Total Syntheses of Lyconadins: Finding Efficiency and Diversity.Synlett : accounts and rapid communications in synthetic organic chemistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang YangDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA) http://www.chem.purdue.edu/dai/
Christopher W Haskins
Wandi Zhang
Pui Leng Low
Mingji Dai

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
NCI NIH HHS P30 CA023168
6 · The paper itself

Abstract

Divergent and concise total syntheses of two lycopodium alkaloids, lyconadins A and C have been developed. The synthesis of lyconadin A, having potent neurotrophic activity, features an efficient one-pot ketal removal and formal aza-[4+2] cyclization to form the cagelike core structure. A tandem ketal removal/Mannich reaction was developed to build the tricyclic structure of lyconadin C. Both lyconadins A and C were synthesized from a pivotal intermediate.

Indexed as

Biological ProductsCyclizationDrug DiscoveryMolecular StructurePolycyclic CompoundsStereoisomerismBiological Productslyconadin CPolycyclic Compoundsalkaloidscyclizationsdrug discoverynatural productstotal synthesis

Identifiers

PMID24596132
PMCPMC4113559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.