ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014
Predictors of mortality attributable to Clostridium difficile infection in patients with underlying malignancy.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Management ofEClinicalMedicine · 2025Review
- Impact ofJournal of Korean medical science · 2025Article
- Risk factors and outcomes of Clostridioides difficile infection in patients with colorectal cancer: critical perspective in management.Gut pathogens · 2025Review
- A Three-Year Analysis of Mortality in Clostridioides difficile Patients in a Tertiary Center.Cureus · 2024Article
- Early de-escalation of antibiotic therapy in hospitalized cellular therapy adult patients with febrile neutropenia.Clinical hematology international · 2024Article
- Article
- Performance of Clostridioides difficile infection severity scores and risk factors related to 30-day all-cause mortality in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Observational
- Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer.Infectious diseases and therapy · 2023Article
- Outcomes ofEuropean journal of hospital pharmacy : science and practice · 2022Article
- Fecal Microbiota Transplant for Hematologic and Oncologic Diseases: Principle and Practice.Cancers · 2022Review
- Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection.Trends in molecular medicine · 2020Review
- Determining the risk factors associated with the development ofBlood research · 2019Article
- Clostridioides difficile Infection in the Stem Cell Transplant and Hematologic Malignancy Population.Infectious disease clinics of North America · 2019Review
- Prognosis of Clostridium difficile infection in adult oncohaematological patients: experience from a large prospective observational study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Observational
- Poorer outcomes among cancer patients diagnosed with Clostridium difficile infections in United States community hospitals.BMC infectious diseases · 2017Article
- Risks factors and outcomes of Clostridium difficile infection in patients with cancer: a matched case-control study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Role of the leukocyte response in normal and immunocompromised host after Clostridium difficile infection.Anaerobe · 2017Review
- Impact of malignancy on Clostridium difficile infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Clostridium difficile Infections amongst Patients with Haematological Malignancies: A Data Linkage Study.PloS one · 2016Article
- Bezlotoxumab for the prevention of recurrentAnnals of gastroenterologyArticle
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Authors and funding
13 authors.
Funding
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Abstract
purposeThis study aimed at evaluating the clinical severity and treatment outcomes of Clostridium difficile infections (CDI) and identifying predictors associated with mortality in patients with malignancy.
methodsA retrospective study was conducted in a teaching hospital from January 2004 to June 2013. The subjects included adult patients (aged ≥ 18 years) receiving treatment for malignancy whose conditions were complicated by CDI. Clinical severity was determined using the guidelines from the Society for Healthcare Epidemiology of America and the Infectious Diseases Society of America (SHEA/IDSA). Multivariate logistic regression analysis was performed to identify predictors independently associated with CDI-related mortality.
resultsOf the 5,594 patients treated for malignancy at the Division of Hematology/Oncology during the study period, 61 (1.1%) had CDI complications. CDI-related mortality was 19.7% (12/61). Twenty-seven (44.3%) patients were diagnosed with neutropenia (ANC ≤ 500/mm(3)) at initial CDI presentation. Forty-one patients (67.2%) received antimicrobial therapy for CDI. Based on the SHEA/IDSA guidelines, only 12 patients (19.7%) presented with severe CDI, but 25 (61.0%) patients experienced treatment failure. Multiple logistic regression modeling showed neutropenia to be an independent risk factor for CDI-related mortality (odds ratio, 5.17; 95% confidence interval, 1.24-21.59).
conclusionsThis study tracked poor CDI treatment outcomes in patients with malignancy and identified neutropenia as a previously unrecognized risk factor of CDI-related mortality. Alternative definitions of severe CDI that include neutropenia might be necessary to more accurately determine clinical severity.
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