ArticleDevelopment (Cambridge, England)2014
Wnt-regulated dynamics of positional information in zebrafish somitogenesis.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- Multimodal optical imaging for the assessment of the teratogenic effects of ethanol on zebrafish development.Journal of biomedical optics · 2026Article
- Rapgef1 paralog-mediated regulation of Wnt/β-catenin signaling orchestrates early embryo tissue patterning and morphogenesis.Cell communication and signaling : CCS · 2026Article
- The physical roles of different posterior tissues in zebrafish axis elongation.Nature communications · 2025Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- Spatiotemporal control of pattern formation during somitogenesis.Science advances · 2024Review
- A design logic for sequential segmentation across organisms.The FEBS journal · 2023Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation.Nature communications · 2022Article
- Patterning principles of morphogen gradients.Open biology · 2022Review
- Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis.Communications biology · 2022Article
- Towards a physical understanding of developmental patterning.Nature reviews. Genetics · 2021Review
- Time and space in segmentation.Interface focus · 2021Article
- Molecular and Mechanical Cues for Somite Periodicity.Frontiers in cell and developmental biology · 2021Review
- Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development.Development (Cambridge, England) · 2020Article
- Detection of mRNA by Whole MountBio-protocol · 2019Article
- Regulatory Network of the Scoliosis-Associated Genes Establishes Rostrocaudal Patterning of Somites in Zebrafish.iScience · 2019Article
- Bioelectrical control of positional information in development and regeneration: A review of conceptual and computational advances.Progress in biophysics and molecular biology · 2018Review
- Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish.Cell reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.