Evidence map›Paper›PMID 24595286›Full record

ReviewDevelopment (Cambridge, England)2014

Shared signaling systems in myeloid cell-mediated muscle regeneration.

James G Tidball, Kenneth Dorshkind, Michelle Wehling-Henricks

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
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  18. Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  19. All for One and One for All: Regenerating Skeletal Muscle.Cold Spring Harbor perspectives in biology · 2022
    Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James G TidballMolecular, Cellular & Integrative Physiology Program, University of California, Los Angeles, CA 90095-1606, USA.
Kenneth Dorshkind
Michelle Wehling-Henricks
University of California, Los Angeles · US

Funding

Functions of myelomonocytic lineage cells in aging muscleR01AG041147 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2011 to 2015
$1.7M
NIA NIH HHS R01 AG041147
6 · The paper itself

Abstract

Much of the focus in muscle regeneration has been placed on the identification and delivery of stem cells to promote regenerative capacity. As those efforts have advanced, we have learned that complex features of the microenvironment in which regeneration occurs can determine success or failure. The immune system is an important contributor to that complexity and can determine the extent to which muscle regeneration succeeds. Immune cells of the myeloid lineage play major regulatory roles in tissue regeneration through two general, inductive mechanisms: instructive mechanisms that act directly on muscle cells; and permissive mechanisms that act indirectly to influence regeneration by modulating angiogenesis and fibrosis. In this article, recent discoveries that identify inductive actions of specific populations of myeloid cells on muscle regeneration are presented, with an emphasis on how processes in muscle and myeloid cells are co-regulated.

Indexed as

AnimalsCell LineageCytokinesFibrosisHumansInflammationMacrophagesModels, BiologicalMuscle DevelopmentMuscle, SkeletalMyeloid CellsRegenerationSignal TransductionCytokinesMacrophage phenotypeMuscle regenerationSignaling systems

Identifiers

PMID24595286
PMCPMC3943178
OpenAlexW1971173086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.