ArticlePloS one2014
Genomic and metabolomic insights into the natural product biosynthetic diversity of a feral-hog-associated Brevibacillus laterosporus strain.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Antibacterial activity and genomic characterisation of a novelJournal of veterinary research · 2025Article
- Action mechanism of the potential biocontrol agent Brevibacillus laterosporus SN19-1 against Xanthomonas oryzae pv. oryzae causing rice bacterial leaf blight.Archives of microbiology · 2023Article
- Atmospheric and Room Temperature Plasma (ARTP) Mutagenesis Improved the Anti-MRSA Activity ofInternational journal of molecular sciences · 2023Article
- Paenibacillus arenilitoris sp. nov., isolated from seashore sand and genome mining revealed the biosynthesis potential as antibiotic producer.Antonie van Leeuwenhoek · 2022Article
- Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals.mSphere · 2021Article
- Cry75Aa (Mpp75Aa) Insecticidal Proteins for Controlling the Western Corn Rootworm,Applied and environmental microbiology · 2021Article
- Characterization and Antimicrobial Studies of Iturin-Like and Bogorol-Like Lipopeptides FromFrontiers in microbiology · 2021Article
- Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian.Frontiers in chemistry · 2021Article
- Novel Modifications of Nonribosomal Peptides from Brevibacillus laterosporus MG64 and Investigation of Their Mode of Action.Applied and environmental microbiology · 2020Article
- Phylogenetic determinants of toxin gene distribution in genomes of Brevibacillus laterosporus.Genomics · 2020Article
- Selecting lipopeptide-producing, Fusarium-suppressing Bacillus spp.: Metabolomic and genomic probing of Bacillus velezensis NWUMFkBS10.5.MicrobiologyOpen · 2019Article
- Role of Proline in Pathogen and Host Interactions.Antioxidants & redox signaling · 2019Review
- The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.Proteins · 2018Article
- Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes.Scientific reports · 2017Article
- Retrospective analysis of natural products provides insights for future discovery trends.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes.Journal of natural products · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Bacteria associated with mammals are a rich source of microbial biodiversity; however, little is known concerning the abilities of these microbes to generate secondary metabolites. This report focuses on a bacterium isolated from the ear of a feral hog from southwestern Oklahoma, USA. The bacterium was identified as a new strain (PE36) of Brevibacillus latersporus, which was shown via genomic analysis to contain a large number of gene clusters presumably involved in secondary metabolite biosynthesis. A scale-up culture of B. latersporus PE36 yielded three bioactive compounds that inhibited the growth of methicillin-resistant Staphylococcus aureus (basiliskamides A and B and 12-methyltetradecanoic acid). Further studies of the isolate's secondary metabolome provided both new (auripyrazine) and previously-described pyrazine-containing compounds. In addition, a new peptidic natural product (auriporcine) was purified that was determined to be composed of a polyketide unit, two L-proline residues, two D-leucine residues, one L-leucine residue, and a reduced L-phenylalanine (L-phenylalanol). An examination of the genome revealed two gene clusters that are likely responsible for generating the basiliskamides and auriporcine. These combined genomic and chemical studies confirm that new and unusual secondary metabolites can be obtained from the bacterial associates of wild mammals.
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