ArticlePloS one2014
Arabidopsis protein phosphatase DBP1 nucleates a protein network with a role in regulating plant defense.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Potato virus Y viral protein 6K1 inhibits the interaction between defense proteins during virus infection.Plant physiology · 2024Article
- Tools and targets: The dual role of plant viruses in CRISPR-Cas genome editing.The plant genome · 2023Review
- Effector-mediated plant-virus-vector interactions.The Plant cell · 2022Review
- Mapping of CaPP2C35 involved in the formation of light-green immature pepper (Capsicum annuum L.) fruits via GWAS and BSA.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor.International journal of molecular sciences · 2020Article
- The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes.Frontiers in plant science · 2020Article
- Current achievements and future directions in genetic engineering of European plum (Prunus domestica L.).Transgenic research · 2018Review
- Nuclear Signaling of Plant MAPKs.Frontiers in plant science · 2018Review
- Phosphoproteomics Profiling of Tobacco Mature Pollen and Pollen Activated in vitro.Molecular & cellular proteomics : MCP · 2016Article
- Recessive Resistance to Plant Viruses: Potential Resistance Genes Beyond Translation Initiation Factors.Frontiers in microbiology · 2016Review
- Biotechnological strategies and tools for Plum pox virus resistance: trans-, intra-, cis-genesis, and beyond.Frontiers in plant science · 2015Review
- 14-3-3 Proteins in Guard Cell Signaling.Frontiers in plant science · 2015Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis thaliana DBP1 belongs to the plant-specific family of DNA-binding protein phosphatases. Although recently identified as a novel host factor mediating susceptibility to potyvirus, little is known about DBP1 targets and partners and the molecular mechanisms underlying its function. Analyzing changes in the phosphoproteome of a loss-of-function dbp1 mutant enabled the identification of 14-3-3λ isoform (GRF6), a previously reported DBP1 interactor, and MAP kinase (MAPK) MPK11 as components of a small protein network nucleated by DBP1, in which GRF6 stability is modulated by MPK11 through phosphorylation, while DBP1 in turn negatively regulates MPK11 activity. Interestingly, grf6 and mpk11 loss-of-function mutants showed altered response to infection by the potyvirus Plum pox virus (PPV), and the described molecular mechanism controlling GRF6 stability was recapitulated upon PPV infection. These results not only contribute to a better knowledge of the biology of DBP factors, but also of MAPK signalling in plants, with the identification of GRF6 as a likely MPK11 substrate and of DBP1 as a protein phosphatase regulating MPK11 activity, and unveils the implication of this protein module in the response to PPV infection in Arabidopsis.
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