ArticlePloS one2014
Improvement of human keratinocyte migration by a redox active bioelectric dressing.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Wound Infections Using Bioelectric Wound Dressings
Prospective, Unblinded, Randomized, Controlled Investigation to Evaluate the Clinical Efficacy of PowerHeal™ Bioelectric Bandage in Managing Infected Traumatic Wounds
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Lack of level I evidence on how to prevent infection after elective shoulder surgery.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing.Scientific reports · 2025Trial
- A Prospective, Randomized, Controlled Study to Evaluate the Effectiveness of a Fabric-Based Wireless Electroceutical Dressing Compared to Standard-of-Care Treatment Against Acute Trauma and Burn Wound Biofilm Infection.Advances in wound care · 2024Trial
- Mechanical, Redox, and Bioelectrical Coupling in Hydrogels for Cutaneous Regeneration: Network Design and Structure-Property Relationships.Gels (Basel, Switzerland) · 2026Review
- A bioelectric dressing improves postderoofing outcomes in hidradenitis suppurativa by microbiome modulation: A split-body, randomized clinical trial.JID innovations : skin science from molecules to population health · 2026Article
- Progress in the application of conductive hydrogels in wound healing: a review.Nanoscale advances · 2026Review
- Advancements in Functional Dressings and a Case for Cotton Fiber Technology: Protease Modulation, Hydrogen Peroxide Generation, and ESKAPE Pathogen Antibacterial Activity.International journal of molecular sciences · 2026Review
- Application of electrospun piezoelectric nanofibers in wound healing.Burns & trauma · 2026Review
- Conductive polymers in smart wound healing: From bioelectric stimulation to regenerative therapies.Materials today. Bio · 2025Review
- Enhancing Burn Recovery: A Systematic Review on the Benefits of Electrical Stimulation in Accelerating Healing.European burn journal · 2025Review
- Advancing Chronic Wound Healing through Electrical Stimulation and Adipose-Derived Stem Cells.Advanced healthcare materials · 2025Review
- Article
- Noninvasive Self-Powered Iontophoresis Mask Based on a Water-Driven Fiber Battery.Research (Washington, D.C.) · 2025Article
- Article
- Electroceuticals: Unlocking the promise of therapies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Bacterial Pyocyanin Inducible Keratin 6A Accelerates Closure of Epithelial Defect under Conditions of Mitochondrial Dysfunction.The Journal of investigative dermatology · 2023Article
- Recent Advances in Functional Wound Dressings.Advances in wound care · 2023Review
- [Research progress of metal micro-battery dressings in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Electrochemical Devices in Cutaneous Wound Healing.Bioengineering (Basel, Switzerland) · 2023Review
- Driving adult tissue repair via re-engagement of a pathway required for fetal healing.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Exogenous application of an electric field can direct cell migration and improve wound healing; however clinical application of the therapy remains elusive due to lack of a suitable device and hence, limitations in understanding the molecular mechanisms. Here we report on a novel FDA approved redox-active Ag/Zn bioelectric dressing (BED) which generates electric fields. To develop a mechanistic understanding of how the BED may potentially influence wound re-epithelialization, we direct emphasis on understanding the influence of BED on human keratinocyte cell migration. Mapping of the electrical field generated by BED led to the observation that BED increases keratinocyte migration by three mechanisms: (i) generating hydrogen peroxide, known to be a potent driver of redox signaling, (ii) phosphorylation of redox-sensitive IGF1R directly implicated in cell migration, and (iii) reduction of protein thiols and increase in integrinαv expression, both of which are known to be drivers of cell migration. BED also increased keratinocyte mitochondrial membrane potential consistent with its ability to fuel an energy demanding migration process. Electric fields generated by a Ag/Zn BED can cross-talk with keratinocytes via redox-dependent processes improving keratinocyte migration, a critical event in wound re-epithelialization.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.