ArticlePloS one2014
The severe adverse reaction to vitamin k1 injection is anaphylactoid reaction but not anaphylaxis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- A randomized, open-label, three-period, cross-over, single intravenous or intramuscular dose, pharmacokinetics and bioequivalence study of vitamin KNaunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Bridging the Gap in the Clinical Application of Advanced Parenteral Nutrition Formulations: From Efficacy to Real-World Challenges.Advances in nutrition (Bethesda, Md.) · 2026Review
- Mechanical ventilation in a case of anticoagulant rodenticide toxicity: a case report.Frontiers in veterinary science · 2026Article
- Effects of Vitamin K Administration in Correcting Coagulopathy in Patients with Liver Cirrhosis: Retrospective Clinical Study.Clinics and practice · 2025Article
- Impact of concerning excipients on animal safety: insights for veterinary pharmacotherapy and regulatory considerations.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Impact of concerning excipients on animal safety: insights for veterinary pharmacotherapy and regulatory considerations.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics.Journal of natural medicines · 2024Article
- Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions.BMC pharmacology & toxicology · 2022Article
- Anaphylactic Rare Saponins Separated fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Preparation and Evaluation of Lipid Emulsion Containing 13 Vitamins for Injection Without Anaphylactoid Reactions.International journal of nanomedicine · 2021Article
- Acinetobacter soli SP2 Capable of High-Efficiency Degradation of Food Emulsifier Polysorbate 80.Current microbiology · 2018Article
- Characterizing the Severe Reactions of Parenteral Vitamin K1.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Review
- Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke.Current treatment options in neurology · 2017Review
- IsToxicology reports · 2017Article
- In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine.Veterinary sciences · 2016Review
- Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period.Medicine · 2016Article
- Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.Neurocritical care · 2016Review
- Proteomics Study on Nonallergic Hypersensitivity Induced by Compound 4880 and Ovalbumin.PloS one · 2016Article
- Intravenous Administration of Vitamin K1 in Dogs and Cats Presented for Anticoagulant Rodenticide Poisoning: A Retrospective Study of 58 Cases.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The severe adverse reaction to vitamin K1 injection is always remarkable and is thought to result from anaphylaxis. Paradoxically, however, some patients administered vitamin K1 injection for the first time have adverse reactions. Using beagle dogs, the present study tested the hypothesis that the response to vitamin K1 is an anaphylactoid reaction. The results showed that serious anaphylaxis-like symptoms appeared in beagle dogs after the administration of vitamin K1 injection for the first time. The plasma histamine concentration increased, and blood pressure decreased sharply. After sensitization, dogs were challenged with vitamin K1 injection and displayed the same degree of symptoms as prior to sensitization. However, when the vitamin K1 injection-sensitized dogs were challenged with a vitamin K1-fat emulsion without solubilizers such asTween-80, the abnormal reactions did not occur. Furthermore, there was no significant change in the plasma immunoglobulin E concentration after vitamin K1 challenge. Following treatment with vitamin K1 injection, the release of histamine and β-hexosaminidase by rat basophilic leukemia-2H3 cells as well as the rate of apoptosis increased. The Tween-80 group displayed results similar to those observed following vitamin K1 injection in vivo. However, the dogs in the vitamin K1-fat emulsion group did not display any abnormal behavior or significant change in plasma histamine. Additionally, degranulation and apoptosis did not occur in rat basophilic leukemia-2H3 cells. Our results indicate that the adverse reaction induced by vitamin K1 injection is an anaphylactoid reaction, not anaphylaxis. Vitamin K1 injection induces the release of inflammatory factors via a non-IgE-mediated immune pathway, for which the trigger may be the solubilizer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.