ArticlePloS one2014
Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 92 citations in OpenAlex.
- Potential Relevance of Amazonian Diet Components in Parkinson's Disease: An Integrative Review with Multivariate Analysis.Nutrients · 2026Review
- Lactic acid bacteria isolated from mammalian feces exhibit distinct diversity and probiotic traits.World journal of microbiology & biotechnology · 2026Article
- Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (International journal of molecular sciences · 2025Article
- Pharmacological effects and phytochemical profile of methanolicFrontiers in pharmacology · 2025Article
- Açaí (Euterpe oleracea Mart.) green synthesis of silver nanoparticles: antimicrobial efficacy and ecotoxicological assessment.Environmental science and pollution research international · 2024Article
- Exotic fruits patents trends: An overview based on technological prospection with a focus on Amazonian.Heliyon · 2023Article
- Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies inACS omega · 2023Review
- Oral Treatment with the Extract ofNutrients · 2023Article
- Açaí (Nutrients · 2023Review
- Phenolic Profile and the Antioxidant, Anti-Inflammatory, and Antimicrobial Properties of Açaí (Foods (Basel, Switzerland) · 2022Article
- Carotenoids from mamey (Biochemistry and biophysics reports · 2021Article
- Caffeic and Dihydrocaffeic Acids Promote Longevity and Increase Stress Resistance inMolecules (Basel, Switzerland) · 2021Article
- In Vitro and In Vivo Antioxidant Activity ofBiomolecules · 2020Article
- Baru Pulp (Biomolecules · 2020Article
- Review
- Exploring Target Genes Involved in the Effect of Quercetin on the Response to Oxidative Stress inAntioxidants (Basel, Switzerland) · 2019Article
- Effects of açai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD.Scientific reports · 2019Article
- Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway.PloS one · 2019Article
- Pasteurized Orange Juice Rich in Carotenoids ProtectsOxidative medicine and cellular longevity · 2019Article
- The value of the Brazilian açai fruit as a therapeutic nutritional strategy for chronic kidney disease patients.International urology and nephrology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Açaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo antioxidant properties of açaí on an organismal level and to examine its mechanism of action. Supplementation with açaí aqueous extract (AAE) increased both oxidative and osmotic stress resistance independently of any effect on reproduction and development. AAE suppressed bacterial growth, but this antimicrobial property did not influence stress resistance. AAE-increased stress resistance was correlated with reduced ROS production, the prevention of sulfhydryl (SH) level reduction and gcs-1 activation under oxidative stress conditions. Our mechanistic studies indicated that AAE promotes oxidative stress resistance by acting through DAF-16 and the osmotic stress response pathway OSR-1/UNC-43/SEK-1. Finally, AAE increased polyglutamine protein aggregation and decreased proteasome activity. Our findings suggest that natural compounds available in AAE can improve the antioxidant status of a whole organism under certain conditions by direct and indirect mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.