Evidence map›Paper›PMID 24594555›Full record

ArticlePharmaceuticals (Basel, Switzerland)2014

Antimicrobial peptides from fish.

Jorge A Masso-Silva, Gill Diamond

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed.

  1. A hepcidin homolog fromVirulence · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jorge A Masso-SilvaDepartment of Pediatrics and Graduate School of Biomedical Sciences, Rutgers New Jersey Medical School, Newark, NJ 07101, USA. massoja@gsbs.rutgers.edu.
Gill DiamondDepartment of Oral Biology, University of Florida, Box 100424, Gainesville, FL 32610, USA. gdiamond@dental.ufl.edu.

Funding

Vitamin D and Periodontal DiseaseR01DE022723 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI DIAMOND, GILL · 2012 to 2014
$791k
Vitamin D and Innate Immunity in Respiratory InfectionsR21AI100379 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CHRISTAKOS, SYLVIA S, DIAMOND, GILL · 2012 to 2013
$431k
NIAID NIH HHS R21 AI100379NIDCR NIH HHS R01 DE022723
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins, cathelicidins, hepcidins, histone-derived peptides, and a fish-specific class of the cecropin family, called piscidins. As with other species, the fish peptides exhibit broad-spectrum antimicrobial activity, killing both fish and human pathogens. They are also immunomodulatory, and their genes are highly responsive to microbes and innate immuno-stimulatory molecules. Recent research has demonstrated that some of the unique properties of fish peptides, including their ability to act even in very high salt concentrations, make them good potential targets for development as therapeutic antimicrobials. Further, the stimulation of their gene expression by exogenous factors could be useful in preventing pathogenic microbes in aquaculture.

Identifiers

PMID24594555
PMCPMC3978493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.