ArticleScientific reports2014
Cephalopod eye evolution was modulated by the acquisition of Pax-6 splicing variants.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio.Molecular biology and evolution · 2026Article
- Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals.Science advances · 2022Article
- Krüppel-like factor/specificity protein evolution in the Spiralia and the implications for cephalopod visual system novelties.Proceedings. Biological sciences · 2020Article
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates.Frontiers in physiology · 2018Review
- Highly Expressed Genes Are Preferentially Co-Opted for C4 Photosynthesis.Molecular biology and evolution · 2018Article
- Ancestral and novel roles of Pax family genes in mollusks.BMC evolutionary biology · 2017Article
- The Pax gene family: Highlights from cephalopods.PloS one · 2017Article
- Eye Development inFrontiers in physiology · 2017Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Previous studies have reported that the developmental processes of vertebrate eyes are controlled by four Pax-6 splicing variants, each modulating different downstream genes, whereas those of insect eyes are controlled by duplicated Pax-6 genes. Cephalopods belong to the Protostomes but possess a camera-type eye similar to those in vertebrates. We examined Pax-6 variations in the squid and found five types of Pax-6 splicing variants but no duplication of the Pax-6 gene. In the five splicing variants, the splicing patterns were produced by the combination of two additional exons to the ortholog and one jettisoned exon containing most of the Homeobox domain (HD). These five variants show spatio-temporal patterns of gene expression during development in the squid. Our study suggests that cephalopods acquired Pax-6 splicing variants independent of those in vertebrates and that these variants were similarly utilized in the development of the squid eye.
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