ArticleJournal of theoretical biology2014
A mathematical model of intrahost pneumococcal pneumonia infection dynamics in murine strains.
Article in Journal of theoretical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A mechanism-based model of immune status effects on antibiotic PK/PD targets in bacteremia.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Mathematical Modeling of the Lethal Synergism of Coinfecting Pathogens in Respiratory Viral Infections: A Review.Microorganisms · 2023Review
- An agent-based model for collaborative learning to combat antimicrobial resistance: proof of concept based on broiler production in Senegal.Science in One Health · 2023Article
- The multilevel hierarchical data EM-algorithm. Applications to discrete-time Markov chain epidemic models.Heliyon · 2022Article
- Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques.Bulletin of mathematical biology · 2021Article
- Modeling the transmission dynamics of delayed pneumonia-like diseases with a sensitivity of parameters.Advances in difference equations · 2021Article
- A mathematical model shows macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance.Journal of theoretical biology · 2020Article
- A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection.PloS one · 2020Article
- Host-pathogen kinetics during influenza infection and coinfection: insights from predictive modeling.Immunological reviews · 2018Review
- Mechanism-Based Disease Progression Model Describing Host-Pathogen Interactions During the Pathogenesis of Acinetobacter baumannii Pneumonia.CPT: pharmacometrics & systems pharmacology · 2018Article
- Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection.Frontiers in physiology · 2017Review
- Mathematical Modeling ofFrontiers in physiology · 2017Article
- Mathematical Models for Immunology: Current State of the Art and Future Research Directions.Bulletin of mathematical biology · 2016Review
- A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice.PloS one · 2016Article
- Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy.Methods in molecular biology (Clifton, N.J.) · 2016Review
- A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.PLoS computational biology · 2015Article
- The inverse problem in mathematical biology.Mathematical biosciences · 2015Review
- A Three-Tiered Study of Differences in Murine Intrahost Immune Response to Multiple Pneumococcal Strains.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The seriousness of pneumococcal pneumonia in mouse models has been shown to depend both on bacterial serotype and murine strain. We here present a simple ordinary differential equation model of the intrahost immune response to bacterial pneumonia that is capable of capturing diverse experimentally determined responses of various murine strains. We discuss the main causes of such differences while accounting for the uncertainty in the estimation of model parameters. We model the bacterial population in both the lungs and blood, the cellular death caused by the infection, and the activation and immigration of phagocytes to the infected tissue. The ensemble model suggests that inter-strain differences in response to streptococcus pneumonia inoculation reside in the strength of nonspecific immune response and the rate of extrapulmonary phagocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.