Evidence map›Paper›PMID 24594368›Full record

ArticleBehavioural brain research2014

Embryonic alcohol exposure impairs associative learning performance in adult zebrafish.

Yohaan Fernandes, Steven Tran, Emil Abraham, Robert Gerlai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Animal Models of Prenatal Alcohol Exposure.Advances in experimental medicine and biology · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Zebrafish models of fetal alcohol spectrum disorders.Genesis (New York, N.Y. : 2000) · 2021
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. ZEBRAFISH AS AN IN VIVO MODEL FOR SUSTAINABLE CHEMICAL DESIGN.Green chemistry : an international journal and green chemistry resource : GC · 2016
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yohaan FernandesDepartment of Cell and System Biology, University of Toronto, Canada.
Steven TranDepartment of Cell and System Biology, University of Toronto, Canada.
Emil AbrahamDepartment of Psychology, University of Toronto, Canada.
Robert GerlaiDepartment of Cell and System Biology, University of Toronto, Canada; Department of Psychology, University of Toronto, Canada. Electronic address: robert_gerlai@yahoo.com.
University of Toronto · CA

Funding

Alcohol and zebra fish: Behavioral screens for mutantsR01AA015325 · NIAAA · UNIVERSITY OF TORONTO · PI GERLAI, ROBERT T. · 2007 to 2011
$1.2M
NIAAA NIH HHS R01 AA015325
6 · The paper itself

Abstract

The zebrafish has been proposed for modeling fetal alcohol spectrum disorders (FASD). Previous FASD research with zebrafish employed high concentrations of alcohol and/or long exposure periods. Here, we exposed zebrafish eggs to low doses of alcohol (0, 0.25, 0.50, 0.75 and 1.0% (vol/vol); external bath application of which 1/20th may reach the inside of the egg) at 16-h post-fertilization (hpf) and only for a short duration (2h) in the hope to avoid gross morphological aberrations and to mimic the more frequent FASD exposure levels. Upon reaching adulthood the exposed and control zebrafish were tested for their associative learning performance in a plus-maze. Embryonic alcohol exposure led to no gross anatomical abnormalities and did not increase mortality. Unexposed (control) zebrafish showed excellent acquisition of association between a conditioned visual stimulus (CS) and food reward, demonstrated by their preference for the target zone of the maze that contained the CS during a probe trial in the absence of reward. However, alcohol-exposed fish showed no such preference and performed indistinguishable from random chance. Locomotor activity during training and the probe trial or the amount of food consumed during training did not differ between the embryonic alcohol exposed and unexposed (control) fish, suggesting that the impaired learning performance found was unlikely to be caused by altered motivation or motor function. Our results suggest that even very small amounts of alcohol reaching the embryo for only a short duration of time may have long lasting deleterious effects on cognitive function in vertebrates.

Indexed as

Analysis of VarianceAnimalsAssociation LearningCentral Nervous System DepressantsDose-Response Relationship, DrugEmbryo, NonmammalianEthanolLearning DisabilitiesMaze LearningZebrafishCentral Nervous System DepressantsEthanolEmbryonic alcohol exposureFetal alcohol spectrum disordersLearning impairmentZebrafish

Identifiers

PMID24594368
PMCPMC4339085
OpenAlexW2035314891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.