ArticlePediatric rheumatology online journal2014
Cervical spine involvement in patients with juvenile idiopathic arthritis - MRI follow-up study.
Article in Pediatric rheumatology online journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Cervical spine arthritis as initial manifestation in Juvenile Idiopathic Arthritis: a multicenter retrospective study.Pediatric rheumatology online journal · 2025Article
- Imaging evaluation of rheumatologic musculoskeletal disorders in children.Skeletal radiology · 2025Review
- Atraumatic atlantoaxial subluxation in pediatric enthesitis-related juvenile idiopathic arthritis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- The Features of Children with Juvenile Idiopathic Arthritis with Cervical Spine Involvement in the Data from a Retrospective Study Cohort.Journal of functional morphology and kinesiology · 2025Article
- Reliability and validity of the pediatric adaptation of the mJOA scale for evaluating cervical spine disorders.Spine deformity · 2024Article
- A clinical perspective on imaging in juvenile idiopathic arthritis.Pediatric radiology · 2024Review
- Magnetic resonance imaging of the musculoskeletal system in the diagnosis of rheumatic diseases in the pediatric population.Reumatologia · 2024Review
- Advances in Musculoskeletal Imaging in Juvenile Idiopathic Arthritis.Biomedicines · 2022Review
- Spinal involvement in juvenile idiopathic arthritis: what do we miss without imaging?Rheumatology international · 2022Observational
- Radiographs and MRI of the Cervical Spine in Juvenile Idiopathic Arthritis: A Cross-Sectional Retrospective Study.Journal of clinical medicine · 2021Article
- Neuropsychological functioning and academic abilities in patients with juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2021Article
- Imaging assessment of children presenting with suspected or known juvenile idiopathic arthritis: ESSR-ESPR points to consider.European radiology · 2020Review
- Is axial magnetic resonance imaging useful in early juvenile spondyloarthritis-preliminary report.Clinical rheumatology · 2020Article
- Current management of juvenile idiopathic arthritis affecting the craniovertebral junction.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Juvenile idiopathic arthritis - the role of imaging from a rheumatologist's perspective.Pediatric radiology · 2018Review
- Clinical and MRI outcome of cervical spine lesions in children with juvenile idiopathic arthritis treated with anti-TNFα drugs early in disease course.Pediatric rheumatology online journal · 2017Article
- The surgical management of atlanto-axial subluxation in juvenile rheumatoid arthritis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
- Expert's comment concerning Grand Rounds case entitled "The surgical management of atlanto-axial subluxation in juvenile rheumatoid arthritis" (Khalid M. I. Salem et al. Eur Spine J; 2014, DOI 10.1007/s00586-014-3648-5).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
- [Current therapy of polyarticular forms of juvenile idiopathic arthritis].Zeitschrift fur Rheumatologie · 2016Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo describe MRI and clinical findings in patients with juvenile idiopathic arthritis with cervical spine involvement at onset and follow-up under therapy.
methods13 patients with signs of cervical spine involvement in juvenile idiopathic arthritis with a median disease duration of 1.7 years were included in the study. Clinical records and MR images were retrospectively analyzed according to symptoms and findings concerning the cervical spine.
resultsAt the onset of cervical spine involvement all patients showed limited range of motion, whereas only 5 of them complained of pain. In MR images joint hyperintensity, contrast enhancement, malalignment, ankylosis, erosion and narrowing of the spinal canal at cranio-cervical junction were found at 28, 32, 15, 2, 2 and 3 sites in 12 (93%), 13 (100%), 8 (62%), 2 (15%), 2 and 3 (20%) patients respectively. 3 of the 5 patients with pain (60%) showed ankylosis, erosions or narrowing of the spinal canal at cranio-cervical junction on MRI. At follow-up - after a median disease duration of cervical spine arthritis of 2.1 years and a variable duration of treatment with methotrexate (all patients) and biological agents (12 patients) - joint hyperintensity, enhancement and malalignment decreased to 15, 19 and 6 sites in 10 (77%), 11 (85%) and 3 (20%) patients respectively whereas ankylosis, erosion and narrowing of the spinal canal at cranio-cervical junction increased to 7, 6 and 4 sites in 3 (20%), 4 (31%) and 4 patients respectively. Pain was no longer reported, but 9 of 13 (69%) patients still had a limited range of motion with 6 of them (46%) showing skeletal changes on MRI.
conclusionsThis first MRI based follow-up study shows that cervical spine arthritis can follow a severe disease course in juvenile arthritis. While malalignments and inflammation sites decreased osseous changes with erosions, ankylosis, and narrowing of the spinal canal increased under treatment despite only minor subjective complaints. Therefore close MRI monitoring of these patients appears to be reasonable.
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