ArticleOrganic letters2014
Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases.
Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Extending the starter-unit selection of a collaborating non-reducing polyketide synthase through rational domain swaps.RSC advances · 2026Article
- Methyltransferase Domain-Focused Genome Mining for Fungal Polyketide Synthases.Small methods · 2024Article
- Combinatorial biosynthesis for the engineering of novel fungal natural products.Communications chemistry · 2024Review
- Penisimplicins A and B: Novel Polyketide-Peptide Hybrid Alkaloids from the FungusMolecules (Basel, Switzerland) · 2024Article
- Basidiomycete non-reducing polyketide synthases function independently of SAT domains.Fungal biology and biotechnology · 2023Article
- The Ketosynthase Domain Controls Chain Length in Mushroom Oligocyclic Polyketide Synthases.Chembiochem : a European journal of chemical biology · 2023Article
- Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.Journal of the American Chemical Society · 2020Article
- Discovery and Elucidation of the Biosynthesis of Aspernidgulenes: Novel Polyenes from Aspergillus Nidulans by Using Serial Promoter Replacement.Chembiochem : a European journal of chemical biology · 2019Article
- Engineering of the Filamentous FungusFrontiers in microbiology · 2018Review
- Modern mass spectrometry for synthetic biology and structure-based discovery of natural products.Natural product reports · 2016Review
- Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons.Organic letters · 2016Article
- Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2016Article
- Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Angewandte Chemie (International ed. in English) · 2016Article
- Recent Advances in Understanding and Engineering Polyketide Synthesis.F1000Research · 2016Review
- Accessing Nature's diversity through metabolic engineering and synthetic biology.F1000Research · 2016Review
- Article
- Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis.Journal of the American Chemical Society · 2015Article
- Synthetic biology of fungal natural products.Frontiers in microbiology · 2015Review
- Recent advances in combinatorial biosynthesis for drug discovery.Drug design, development and therapy · 2015Review
- Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the nonreduced polyketide synthase (NR-PKS) AfoE of the asperfuranone pathway with the SAT domains from 10 other NR-PKSs. The newly created hybrid with the NR-PKS AN3386 is able to accept a longer starter unit in place of the native substrate to create a novel aromatic polyketide in vivo.
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Registered trials
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