Evidence map›Paper›PMID 24592996›Full record

ArticleGenetics, selection, evolution : GSE2014

Assessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle.

Ana M Pérez O'Brien, Yuri T Utsunomiya, Gábor Mészáros, Derek M Bickhart, George E Liu, Curtis P Van Tassell, Tad S Sonstegard, Marcos V B Da Silva, José Fernando Garcia, Johann Sölkner

Open access · goldAbstract read
In one paragraph

Article in Genetics, selection, evolution : GSE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  11. Uncovering the architecture of selection in twoEvolutionary applications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Ana M Pérez O'Brien
Yuri T Utsunomiya
Gábor Mészáros
Derek M Bickhart
George E Liu
Curtis P Van Tassell
Tad S Sonstegard
Marcos V B Da Silva
José Fernando Garcia
Johann SölknerUniversity of Natural Resources and Life Sciences, Vienna, Austria. johann.soelkner@boku.ac.at.
BOKU University · ATUniversidade Estadual Paulista (Unesp) · BRBrazilian Agricultural Research Corporation · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSignatures of selection are regions in the genome that have been preferentially increased in frequency and fixed in a population because of their functional importance in specific processes. These regions can be detected because of their lower genetic variability and specific regional linkage disequilibrium (LD) patterns.

methodsBy comparing the differences in regional LD variation between dairy and beef cattle types, and between indicine and taurine subspecies, we aim at finding signatures of selection for production and adaptation in cattle breeds. The VarLD method was applied to compare the LD variation in the autosomal genome between breeds, including Angus and Brown Swiss, representing taurine breeds, and Nelore and Gir, representing indicine breeds. Genomic regions containing the top 0.01 and 0.1 percentile of signals were characterized using the UMD3.1 Bos taurus genome assembly to identify genes in those regions and compared with previously reported selection signatures and regions with copy number variation.

resultsFor all comparisons, the top 0.01 and 0.1 percentile included 26 and 165 signals and 17 and 125 genes, respectively, including TECRL, BT.23182 or FPPS, CAST, MYOM1, UVRAG and DNAJA1.

conclusionsThe VarLD method is a powerful tool to identify differences in linkage disequilibrium between cattle populations and putative signatures of selection with potential adaptive and productive importance.

Indexed as

Linkage DisequilibriumSelection, GeneticAnimalsBreedingCattleDNA Copy Number VariationsGene FrequencyGenomeGenotypeHaplotypes

Identifiers

PMID24592996
PMCPMC4014805
OpenAlexW2102458984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.