ArticleRadiology2014
Carotid artery plaque morphology and composition in relation to incident cardiovascular events: the Multi-Ethnic Study of Atherosclerosis (MESA).
Article in Radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01212900. Cited by 58 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The RIGHT Study: Risk Stratification With Image Guidance of HMG Coa Reductase Inhibitor Therapy
Open the trial in the graphWho cites it
58 citing papers in PubMed, 6 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Meta-Analysis of Intensive Lipid-Lowering Therapy in Patients With Polyvascular Disease.Journal of the American Heart Association · 2021Pooled it
- Pooled it
- Relation between age and carotid artery intima-medial thickness: a systematic review.Clinical cardiology · 2018Pooled it
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Association of metabolic syndrome with carotid thickening and plaque in the general population: A meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- 5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.Journal of the American Heart Association · 2016Pooled it
- Symptomatic Non-stenotic Carotid Disease in Embolic Stroke of Undetermined Source : Analysis of the ESCAPE-NA1 Trial.Clinical neuroradiology · 2024Trial
- Cardiovascular risk factors and carotid plaque components in a multi-ethnic cohort using 3 Tesla MRI: the HELIUS study.European radiology · 2026Article
- Urgent/emergent carotid revascularization is associated with an increase in stroke and mortality.Journal of vascular surgery · 2025Observational
- Incidental Finding of Coronary and Non-Coronary Artery Calcium: What Do Clinicians Need To Know?Current atherosclerosis reports · 2025Review
- Research on ischemic stroke risk assessment based on CTA radiomics and machine learning.BMC medical imaging · 2025Article
- Study on the prediction of short-term clinical changes after cerebral infarction using carotid plaque ultrasound strain elastography.Frontiers in neurology · 2025Article
- Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design.Frontiers in cardiovascular medicine · 2025Article
- Unseen threat: how subclinical atherosclerosis increases mortality risk in patients with type 1 diabetes.Cardiovascular diabetology · 2024Observational
- Atherosclerosis in Patients with Congenital Hemophilia: A Focus on Peripheral Artery Disease.Life (Basel, Switzerland) · 2023Review
- Blind spectral unmixing for characterization of plaque composition based on multispectral photoacoustic imaging.Scientific reports · 2023Article
- Multimodal ultrasound-based carotid plaque risk biomarkers predict poor functional outcome in patients with ischemic stroke or TIA.BMC neurology · 2023Article
- CT angiography-based radiomics as a tool for carotid plaque characterization: a pilot study.La Radiologia medica · 2022Article
- A preliminary study of relationship among the degree of internal carotid artery stenosis, wall shear stress on MR angiography andJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Imaging Approaches to the Diagnosis of Vascular Diseases.Current atherosclerosis reports · 2022Review
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
purposeTo determine if carotid plaque morphology and composition with magnetic resonance (MR) imaging can be used to identify asymptomatic subjects at risk for cardiovascular events. MATERIALS AND
methodsInstitutional review boards at each site approved the study, and all sites were Health Insurance Portability and Accountability Act (HIPAA) compliant. A total of 946 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) were evaluated with MR imaging and ultrasonography (US). MR imaging was used to define carotid plaque composition and remodeling index (wall area divided by the sum of wall area and lumen area), while US was used to assess carotid wall thickness. Incident cardiovascular events, including myocardial infarction, resuscitated cardiac arrest, angina, stroke, and death, were ascertained for an average of 5.5 years. Multivariable Cox proportional hazards models, C statistics, and net reclassification improvement (NRI) for event prediction were determined.
resultsCardiovascular events occurred in 59 (6%) of participants. Carotid IMT as well as MR imaging remodeling index, lipid core, and calcium in the internal carotid artery were significant predictors of events in univariate analysis (P < .001 for all). For traditional risk factors, the C statistic for event prediction was 0.696. For MR imaging remodeling index and lipid core, the C statistic was 0.734 and the NRI was 7.4% and 15.8% for participants with and those without cardiovascular events, respectively (P = .02). The NRI for US IMT in addition to traditional risk factors was not significant.
conclusionThe identification of vulnerable plaque characteristics with MR imaging aids in cardiovascular disease prediction and improves the reclassification of baseline cardiovascular risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.