ArticleJournal of medicinal chemistry2014
Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors.
Article in Journal of medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 81 citations in OpenAlex.
- Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Cinnamaldehyde Targets the LytTR DNA-Binding Domain of the Response Regulator AgrA to Attenuate Biofilm Formation of Listeria monocytogenes.Microbiology spectrum · 2023Article
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
- Recent advances in the multicomponent synthesis of heterocycles using tetronic acid.RSC advances · 2023Review
- Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation inMicrobiology (Reading, England) · 2023Article
- Critical Assessment of the Prospects of Quorum-Quenching Therapy forInternational journal of molecular sciences · 2023Review
- Development ofFrontiers in reproductive health · 2023Article
- Conformational analysis and interaction of theFrontiers in chemistry · 2023Article
- A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin.Cell chemical biology · 2022Article
- Anti-Inflammatory Effects of Analogues ofInternational journal of molecular sciences · 2020Article
- Gaussia Luciferase as a Reporter for Quorum Sensing inSensors (Basel, Switzerland) · 2020Article
- New Vocabulary for Bacterial Communication.Chembiochem : a European journal of chemical biology · 2020Review
- A Simple Polymicrobial Biofilm Keratinocyte Colonization Model for Exploring Interactions Between Commensals, Pathogens and Antimicrobials.Frontiers in microbiology · 2020Article
- Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens.International journal of molecular sciences · 2019Review
- Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor.ACS infectious diseases · 2019Article
- Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression.Journal, genetic engineering & biotechnology · 2018Review
- Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections.Antimicrobial agents and chemotherapy · 2017Article
- Defining motility in the Staphylococci.Cellular and molecular life sciences : CMLS · 2017Review
- VLP-based vaccine induces immune control of Staphylococcus aureus virulence regulation.Scientific reports · 2017Article
- 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2017Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal cell colonization and arthritis in a murine infection model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.