ArticleBioMed research international2014
Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Effects of curcumin on inflammatory and oxidative stress related markers in rat models of experimental arthritis: a systematic review and meta-analysis.Inflammopharmacology · 2026Pooled it
- Pooled it
- A systematic review: Role of dietary supplements on markers of exercise-associated gut damage and permeability.PloS one · 2022Pooled it
- Curcumin and Cancer Stem Cells: Epigenetic Mechanisms Underlying Therapeutic Resistance and Tumor Relapse.International journal of molecular sciences · 2026Review
- A market and risk assessment of 125 turmeric supplements available in Australia, Germany, India, UK, and USA.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Antioxidants in Age-Related Macular Degeneration: Lights and Shadows.Antioxidants (Basel, Switzerland) · 2025Review
- Investigating Bioavailability of Curcumin and Piperine Combination in Comparison to Turmeric Rhizomes: An in vitro Study.Journal of experimental pharmacology · 2024Article
- Pharmacological Mechanisms and Clinical Applications of Curcumin: Update.Aging and disease · 2023Review
- Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials.ACS pharmacology & translational science · 2023Review
- Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?ACS omega · 2023Review
- Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials.International journal of molecular sciences · 2023Article
- The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation.Neurochemical research · 2022Review
- Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside.International journal of molecular sciences · 2022Review
- Improving Curcumin Bioavailability: Current Strategies and Future Perspectives.Pharmaceutics · 2021Review
- Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review.Molecules (Basel, Switzerland) · 2020Review
- The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells into Mesodermal Lineage.Molecules (Basel, Switzerland) · 2019Review
- Curcumin and Heme Oxygenase: Neuroprotection and Beyond.International journal of molecular sciences · 2019Review
- Current status and future prospective of Curcumin as a potential therapeutic agent in the treatment of colorectal cancer.Journal of cellular physiology · 2018Review
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHeme oxygenase-1 (HO-1) has been proposed to exert pharmacological benefits by its antioxidative and anti-inflammatory effects. HO-1 expression may be affected by the GT length polymorphism in the promoter region of the HO-1 gene. We investigated the inducibility of HO-1 by orally administered curcumin in healthy male subjects and its correlation with the GT length polymorphism.
methodsIn an open label uncontrolled phase-1 pilot study, ten male subjects received 12 g of oral curcumin. To investigate the effects of the GT length polymorphism on the inducibility of HO-1, five subjects with homozygous short and five with homozygous long GT genotypes were studied. Plasma concentrations of curcumin, bilirubin, HO-1 mRNA, and protein expression in peripheral blood mononuclear cells (PBMCs) were analyzed over 48 hours.
resultsAt a detection limit of 1 µg/mL curcumin could not be detected in plasma of any subject. Compared to baseline, HO-1 mRNA and protein levels were not induced in PBMCs at any time point up to 48 hours. There was no correlation between any of the parameters and GT length polymorphism.
conclusionsOral curcumin administration has low bioavailability and does not induce HO-1 on mRNA or protein level in PBMCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.