ArticleIranian journal of basic medical sciences2014
Effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Advances in vibration therapy for the treatment of osteoporosis.Frontiers in endocrinology · 2025Review
- Effects of whole body vibration on bone properties in growing rats.International biomechanics · 2022Article
- Whole Body Vibration: A Valid Alternative Strategy to Exercise?Journal of functional morphology and kinesiology · 2022Review
- Chronic whole body vibration ameliorates hippocampal neuroinflammation, anxiety-like behavior, memory functions and motor performance in aged male rats dose dependently.Scientific reports · 2022Article
- Ovariectomized rat model of osteoporosis: a practical guide.EXCLI journal · 2020Review
- Elevated Levels of Peripheral Kynurenine Decrease Bone Strength in Rats with Chronic Kidney Disease.Frontiers in physiology · 2017Article
- Article
- Mechanical competence of ovariectomy-induced compromised bone after single or combined treatment with high-frequency loading and bisphosphonates.Scientific reports · 2015Article
- Combination treatment with whole body vibration and a kidney-tonifying herbal Fufang prevent osteoporosis in ovariectomized rats.Orthopaedic surgery · 2015Article
- Pantoprazole, a proton pump inhibitor, increases orthodontic tooth movement in rats.Iranian journal of basic medical sciences · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): Studies have reported that whole body vibration (WBV) played a vital role in bone remodeling. Circulating serotonin is also involved in negative regulating bone mass in rodents and humans. However, both WBV and inhibition of serotonin biosynthesis may suppress receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis in vitro. The purpose of the current study was to investigate the effect of WBV therapy on the levels of serum serotonin in ovariectomized rats. MATERIALS AND
methodsThirty-six-month-old female Sprague Dawley rats weighing 276.15±37.75 g were ovariectomized to induce osteoporosis, and another ten rats underwent sham operation to establish sham control (SHAM) group. After 3 months, ovariectomized rats were divided into three subgroups and then separately treated with WBV, Alendronate (ALN) and normal saline (OVX), SHAM group was given normal saline. After 6 weeks of treatment, rats were sacrificed. Serum serotonin, RANKL, bone turnover markers, and bone mineral density (BMD), bone strength were evaluated.
resultsThe serum serotonin level was significantly lower in WBV group than OVX and ALN groups (P<0.05 and P<0.001). RANKL levels significantly decreased in WBV and ALN groups compared to OVX group (P<0.001 for both). BMD and biomechanical parameters of femur significantly increased (P<0.05 for both) and bone turnover levels decreased (P<0.001 for both) in WBV group compared to OVX group.
conclusionThese data indicated that WBV enhanced the bone strength and BMD in ovariectomized rats most likely by reducing the levels of circulating serotonin.
Indexed as
Identifiers
24592309PMC3938888W1580017093What OpenQuestion holds
Registered trials
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