ArticleIranian journal of basic medical sciences2014
Effects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Distinct serum and cerebrospinal fluid metabolic signatures associate with pain and fatigue in knee osteoarthritis.Brain, behavior, & immunity - health · 2026Article
- The role of histamine HPharmacology research & perspectives · 2024Article
- CNS-Sparing Histamine HBiomolecules · 2022Article
- Histamine, histamine receptors, and neuropathic pain relief.British journal of pharmacology · 2020Review
- Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain.Frontiers in neuroscience · 2019Review
- Effects of intracerebroventricular injection of vitamin BVeterinary research forum : an international quarterly journal · 2018Article
- Role of μ-opioid receptor in parafascicular nucleus of thalamus on morphine-induced antinociception in a rat model of acute trigeminal pain.Veterinary research forum : an international quarterly journal · 2017Article
- Transmission pathways and mediators as the basis for clinical pharmacology of pain.Expert review of clinical pharmacology · 2016Article
- Role of the thalamic submedius nucleus histamine H1 and H 2 and opioid receptors in modulation of formalin-induced orofacial pain in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Microinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model.Iranian journal of basic medical sciences · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain. MATERIAL AND
methodsTwo stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inflammatory pain was induced by subcutaneous (SC) injection of formalin (50 µl, 2.5%) in the ventral surface of right hind paw. Time durations of licking/biting of the injected paw were recorded as a pain measure.
resultsFormalin produced a biphasic pattern of licking/biting of the injected paw. Histamine at doses of 0.5, 1, and 2 µg decreased the intensity of pain. Chlorpheniramine and ranitidine at the same doses of 1 and 4 µg had no effects, whereas thioperamide at a dose of 4 µg suppressed both phases of formalin-induced pain. Pretreatments with chlorpheniramine and ranitidine at the same dose of 4 µg prevented histamine (2 µg)-induced antinociception. Antinociceptive effects were observed when thioperamide at doses of 1 and 4 µg was used with 0.25 and 1 µg of histamine, respectively. The antinociceptive effects induced by histamine (2 µg) and thioperamide (4 µg) were prevented by prior treatment with naloxone (4 µg).
conclusionThese results indicate that at PSC levels, histamine through post-synaptic H1, H2, and pre-synaptic H3 receptors might be involved in pain modulation. The endogenous opioid system may be involved in histamine- and thioperamide-induced antinociception.
Indexed as
Identifiers
24592308PMC3938887W2136084910What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.