ArticleIranian journal of basic medical sciences2014
Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Impact ofNutrients · 2020Pooled it
- Dietary carotenoids to improve hypertension.Heliyon · 2023Review
- Artificial Intelligence Uncovers Natural MMP Inhibitor Crocin as a Potential Treatment of Thoracic Aortic Aneurysm and Dissection.Frontiers in cardiovascular medicine · 2022Article
- Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Protective effect of crocin on bisphenol A - induced spatial learning and memory impairment in adult male rats: Role of oxidative stress and AMPA receptor.Iranian journal of basic medical sciences · 2020Article
- Anti-hypertensive effect of crocin and hesperidin combination in high-fat diet treated rats.Experimental and therapeutic medicine · 2020Article
- Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK.Saudi journal of biological sciences · 2020Article
- The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study.Diabetology & metabolic syndrome · 2020Article
- The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Toxicology effects of saffron and its constituents: a review.Iranian journal of basic medical sciences · 2017Review
- Study of Crocin & Radiotherapy-induced Cytotoxicity and Apoptosis in the Head and Neck Cancer (HN-5) Cell Line.Iranian journal of pharmaceutical research : IJPR · 2017Article
- The Relaxant Activity of Safranal in Isolated Rat Aortas is Mediated Predominantly via an Endothelium-Independent Mechanism: -Vasodilatory mechanism of safranal.Journal of pharmacopuncture · 2016Article
- Dietary saffron reduced the blood pressure and prevented remodeling of the aorta in L-NAME-induced hypertensive rats.Iranian journal of basic medical sciences · 2015Article
- Saffron as an antidote or a protective agent against natural or chemical toxicities.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Review
- Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat.Iranian journal of basic medical sciences · 2014Article
- The effect of saffron (Avicenna journal of phytomedicineArticle
- Crocin prevents acute angiotensin II-induced hypertension in anesthetized rats.Avicenna journal of phytomedicineArticle
- Effects of Crocin Supplementation during In Vitro Maturation of Mouse Oocytes on Glutathione Synthesis and Cytoplasmic Maturation.International journal of fertility & sterilityArticle
- Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms.Avicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): In this study, the effects of chronic administration of crocin, an active constituent of saffron, on blood pressures of normotensive and desoxycorticosterone acetate (DOCA) - salt induced hypertensive rats, were investigated. MATERIALS AND
methodsFive week administration of three doses of crocin (50, 100 and 200 mg/kg/day) and spironolactone (50 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 4 weeks treatment by DOCA-salt) was carried out and their effects on mean systolic blood pressure (MSBP) and heart rate (HR) were evaluated using tail cuff method. The duration of effect of crocin on SBP, was also evaluated.
resultsOur results indicated that chronic administration of crocin could reduce the MSBP in DOCA salt treated rats in a dose dependent manner. Crocin did not decrease the MSBP in normotensive rats. The data also showed that antihypertensive effects of crocin did not persist.
conclusionIt is concluded that crocin possesses antihypertensive and normalizing effect on BP in chronic administration.
Indexed as
Identifiers
24592301PMC3938880W1589103798What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.