ArticleIranian journal of basic medical sciences2014
Evaluation of immune response after moderate and overtraining exercise in wistar rat.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Effects of cranberry (Journal of the International Society of Sports Nutrition · 2017Trial
- Impact of moderate treadmill training on cytokine levels in rats: influence of age and sex.Frontiers in aging · 2026Article
- Exercise workload: a key determinant of immune health - a narrative review.Frontiers in immunology · 2025Review
- Voluntary exercise improves pulmonary inflammation through NF-κB and Nrf2 in type 2 diabetic male rats.Iranian journal of basic medical sciences · 2024Article
- Differential Expression of Innate and Adaptive Immune Genes during Acute Physical Exercise in American Quarter Horses.Animals : an open access journal from MDPI · 2023Article
- IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance.Scandinavian journal of medicine & science in sports · 2023Review
- Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation.Frontiers in immunology · 2023Review
- A Guide to Different Intensities of Exercise, Vaccination, and Sports Nutrition in the Course of Preparing Elite Athletes for the Management of Upper Respiratory Infections during the COVID-19 Pandemic: A Narrative Review.International journal of environmental research and public health · 2022Review
- Whey Protein Supplementation Effects on Body Composition, Performance, and Blood Biomarkers During Army Initial Entry Training.Frontiers in nutrition · 2022Article
- Article
- Chronic Aerobic Training at Different Volumes in the Modulation of Macrophage Function andFrontiers in microbiology · 2021Article
- Intramuscular mechanisms of overtraining.Redox biology · 2020Review
- Spirulina platensis prevents oxidative stress and inflammation promoted by strength training in rats: dose-response relation study.Scientific reports · 2020Article
- Exercise and Dementia.Advances in experimental medicine and biology · 2020Review
- The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats.The journal of physiological sciences : JPS · 2019Article
- The effects of exercise on hippocampal inflammatory cytokine levels, brain oxidative stress markers and memory impairments induced by lipopolysaccharide in rats.Metabolic brain disease · 2019Article
- Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's.Metabolic brain disease · 2019Review
- The role of E3 ubiquitin ligase seven in absentia homolog in the innate immune system: An overview.Veterinary world · 2018Review
- Cytokine Pattern is Affected by Training Intensity in Women Futsal Players.Immune network · 2016Article
- Moderate Aerobic Training Improves Cardiorespiratory Parameters in Elastase-Induced Emphysema.Frontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): The effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study. MATERIALS AND
methodsMale Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (OT) (V=25 m/min, 60min/day for 6 days a week, 11 weeks) and recovered overtrained (OR) (OT plus 2 weeks recovery) groups, (n=6 for each group). Immediately, 24 hr and 2 weeks (in OR) after last bout of exercise blood samples were obtained. The plasma concentrations of TNFα, IL-6, IL-10, IL-4 and IFN were measured by ELISA method.
resultsImmediately after last bout of exercise the following findings were observed; IL-6, IL-10 and TNFα concentrations increased in OT and OR groups compared with control (P<0.05-P<0.001). Serum level of IL-4 decreased (P<0.01) but IFN increased (P<0.05) in MT group vs. control. In addition, circulatory levels of TNFα, IL-6, IL-10 and IL-4 were higher but the IFN concentrations were lower in OT and OR groups than MT group (P<0.05-P<0.01). The IFN-γ/IL4 ratio was significantly increased in MT (P<0.01) while it decreased in OT group. There were not statistical differences in TNFα, IL-6, and IFN levels between different time intervals after exercise in MT, OT and OR groups.
conclusionThese data confirm a positive effect of moderate exercise on immune function and a decrease in susceptibility to viral infection by inducing Th1 cytokine profile shift. However, prolonged and overtraining exercise causes numerous changes in immunity that possibly reflects physiological stress and immune suppression.
Indexed as
Identifiers
24592300PMC3938879W2253772797What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.