Evidence map›Paper›PMID 24592282›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2014

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A (1) H NMR-Based Metabolomic Study.

Zishan Gao, Xuguang Liu, Shuguang Yu, Qi Zhang, Qin Chen, Qiaofeng Wu, Juan Liu, Bo Sun, Li Fang, Jia Lin and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  13. Scientific reports · 2017
    Article
  14. Electroacupuncture atNeural regeneration research · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Zishan GaoClinical Acupuncture and Moxibustion Department, Second School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China ; Acupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China.
Xuguang LiuAcupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China.
Shuguang YuAcupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China.
Qi ZhangNational Center of Biomedical Analysis, Beijing 100850, China.
Qin ChenThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China.
Qiaofeng WuAcupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China.
Juan LiuNational Center of Biomedical Analysis, Beijing 100850, China.
Bo SunNational Center of Biomedical Analysis, Beijing 100850, China.
Li FangThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China.
Jia LinDepartment of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
Bing-Mei ZhuClinical Acupuncture and Moxibustion Department, Second School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Xianzhong YanNational Center of Biomedical Analysis, Beijing 100850, China.
Fanrong LiangAcupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China.
Chengdu University · CNNational Center of Biomedical Analysis · CNThe Third Affiliated Hospital of Zhejiang Chinese Medical University · CNNanjing University of Chinese Medicine · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. The objective of this study was to identify potential biomarkers of electroacupuncture (EA) on relieving acute migraine through metabolomic study. Methods. EA treatments were performed on both acupoints and nonacupoints on the nitroglycerin (NTG)-induced migraine rat model. NMR experiments and multivariate analysis were used for metabolomic analysis. Results. The number of head-scratching, the main ethology index of migraine rat model, was significantly increased (P < 0.01) after NTG injection. The plasma metabolic profile of model group was distinct from that of the control group. Glutamate was significantly increased (P < 0.01), whereas lipids were significantly decreased (P < 0.01) in model rats. After EA at acupoints, the metabolic profile of model rats was normalized, with decreased glutamate (P < 0.05) and increased lipids (P < 0.01). In contrast, EA at nonacupoints did not restore the metabolic profile, but with six metabolites significantly different from acupoints group. Interestingly, the number of head-scratching and glutamate level were significantly decreased (P < 0.05) after receiving EA at both acupoints and nonacupoints. Conclusions. EA at acupoints may relieve acute migraine by restoring the plasma metabolic profile and plasma glutamate, while EA at nonacupoints may modestly relieve acute migraine by decreasing plasma glutamate.

Identifiers

PMID24592282
PMCPMC3921982
OpenAlexW2061464639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.