ArticleFrontiers in immunology2014
From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection.
Article in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice.Nature communications · 2025Article
- Stochastic journeys of cell progenies through compartments and the role of self-renewal, symmetric and asymmetric division.Scientific reports · 2024Article
- Protective effects ofFrontiers in pharmacology · 2024Article
- An integrative mechanistic model of thymocyte dynamics.Frontiers in immunology · 2024Article
- Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression.Cancer immunology, immunotherapy : CII · 2023Article
- Transcriptome-based measurement of CD8Trends in immunology · 2023Review
- Article
- Why are cell populations maintained via multiple compartments?Journal of the Royal Society, Interface · 2022Article
- Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.Nature communications · 2022Article
- Modeling the Dynamics of T-Cell Development in the Thymus.Entropy (Basel, Switzerland) · 2021Review
- Liver X receptors are required for thymic resilience and T cell output.The Journal of experimental medicine · 2020Article
- Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.The Journal of clinical investigation · 2020Article
- Article
- Quantitative analysis reveals reciprocal regulations underlying recovery dynamics of thymocytes and thymic environment in mice.Communications biology · 2019Article
- Impact of the Microbiome on the Immune System.Critical reviews in immunology · 2019Review
- Fate of a Naive T Cell: A Stochastic Journey.Frontiers in immunology · 2019Review
- Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery.Journal of mathematical biology · 2017Article
- Modeling the development of the post-natal mouse thymus in the absence of bone marrow progenitors.Scientific reports · 2016Article
- The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus.Frontiers in immunology · 2015Review
- Apoptosis level in developing T cells in the thymus.Doklady. Biochemistry and biophysics · 2015Article
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7 authors.
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Abstract
Cells of the mature αβ T cell repertoire arise from the development in the thymus of bone marrow precursors (thymocytes). αβ T cell maturation is characterized by the expression of thousands of copies of identical αβ T cell receptors and the CD4 and/or CD8 co-receptors on the surface of thymocytes. The maturation stages of a thymocyte are: (1) double negative (DN) (TCR(-), CD4(-) and CD8(-)), (2) double positive (DP) (TCR(+), CD4(+) and CD8(+)), and (3) single positive (SP) (TCR(+), CD4(+) or CD8(+)). Thymic antigen presenting cells provide the appropriate micro-architecture for the maturation of thymocytes, which "sense" the signaling environment via their randomly generated TCRs. Thymic development is characterized by (i) an extremely low success rate, and (ii) the selection of a functional and self-tolerant T cell repertoire. In this paper, we combine recent experimental data and mathematical modeling to study the selection events that take place in the thymus after the DN stage. The stable steady state of the model for the pre-DP, post-DP, and SP populations is identified with the experimentally measured cell counts from 5.5- to 17-week-old mice. We make use of residence times in the cortex and the medulla for the different populations, as well as recently reported asymmetric death rates for CD4 and CD8 SP thymocytes. We estimate that 65.8% of pre-DP thymocytes undergo death by neglect. In the post-DP compartment, 91.7% undergo death by negative selection, 4.7% become CD4 SP, and 3.6% become CD8 SP. Death by negative selection in the medulla removes 8.6% of CD4 SP and 32.1% of CD8 SP thymocytes. Approximately 46.3% of CD4 SP and 27% of CD8 SP thymocytes divide before dying or exiting the thymus.
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