ReviewFrontiers in physiology2014
Neocytolysis: none, one or many? A reappraisal and future perspectives.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Hemolysis during and after 21 days of head-down-tilt bed rest.Physiological reports · 2017Trial
- Enhanced Nucleated Red Blood Cell Production but Ineffective Reticulocyte Differentiation in Preterm Growth-Restricted Infants.International journal of laboratory hematology · 2026Article
- Identifying and Analyzing Low Energy Availability in Athletes: The Role of Biomarkers and Red Blood Cell Turnover.Nutrients · 2024Review
- A new role for erythropoietin in the homeostasis of red blood cells.Communications biology · 2024Article
- Scaling Pharmacodynamics from Rats to Humans to Support Erythropoietin and Romiplostim Combination Therapy to Treat Erythropoietin-Resistant Anemia.Pharmaceutics · 2023Article
- Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists.Frontiers in physiology · 2023Article
- Understanding the Behaviour of Human Cell Types under Simulated Microgravity Conditions: The Case of Erythrocytes.International journal of molecular sciences · 2022Article
- In Vitro Erythropoiesis at Different pOCells · 2022Article
- Related Factors of Anemia in Critically Ill Patients: A Prospective Multicenter Study.Journal of clinical medicine · 2022Article
- A quantitative systems pharmacology model of hyporesponsiveness to erythropoietin in rats.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Six degrees head-down tilt bed rest caused low-grade hemolysis: a prospective randomized clinical trial.NPJ microgravity · 2021Article
- Hyperhaemolytic Syndrome in Sickle Cell Disease: Clearing the Cobwebs.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Review
- Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Contemporary Periodization of Altitude Training for Elite Endurance Athletes: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2019Review
- Red Blood Cells: Chasing Interactions.Frontiers in physiology · 2019Review
- The Red Blood Cells on the Move!Frontiers in physiology · 2018Article
- Neocytolysis: How to Get Rid of the Extra Erythrocytes Formed by Stress Erythropoiesis Upon Descent From High Altitude.Frontiers in physiology · 2018Review
- The potential of erythrocytes as cellular aging models.Cell death and differentiation · 2017Article
- How do red blood cells know when to die?Royal Society open science · 2017Article
- Alterations in hematologic indices during long-duration spaceflight.BMC hematology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neocytolysis is the hypothesis formulated to explain experimental evidence of selective lysis of young red blood cells (RBCs) (neocytes) associated with decreased plasma levels of erythropoietin (EPO). In humans, it appears to take place whenever a fast RBC mass reduction is required, i.e., in astronauts during the first days of spaceflight under weightlessness, where a fast reduction in plasma volume and increase in haematocrit occur. EPO plasma levels then decline and a decrease in RBC mass takes place, apparently because of the selective lysis of the youngest, recently generated RBCs (neocytes). The same process seems to occur in people descending to sea level after acclimatization at high altitude. After descent, the polycythaemia developed at high altitude must be abrogated, and a rapid reduction in the number of circulating RBCs is obtained by a decrease in EPO synthesis and the lysis of what seem to be young RBCs. In vivo, neocytolysis seems to be abolished by EPO administration. More recent research has ascribed to neocytolysis the RBC destruction that occurs under such disparate pathophysiologic conditions as nephropathy, severe obstructive pulmonary disease, blood doping, and even malaria anaemia. According to the theory, EPO's central role would be not only to stimulate the production of new RBCs in conditions of anaemia, as maintained by the orthodox view, but also that of a cytoprotective factor for circulating young RBCs. Why neocytes are specifically destroyed and how is this related to decreased EPO levels has not yet been elucidated. Changes in membrane molecules of young RBCs isolated from astronauts or mountain climbers upon return to normal conditions seem to indicate a higher susceptibility of neocytes to ingestion by macrophages. By limiting the context to space missions and high altitude expeditions, this review will address unresolved and critical issues that in our opinion have not been sufficiently highlighted in previous works.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.