ArticleFrontiers in human neuroscience2014
Moderate relationships between NAA and cognitive ability in healthy adults: implications for cognitive spectroscopy.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- 1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla.PloS one · 2018Trial
- The Case for Vinegar Ingestion.Nutrients · 2026Review
- Article
- Concentrations of glutamate andFrontiers in molecular neuroscience · 2024Article
- Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome.Brain sciences · 2023Article
- White matter and neurochemical mechanisms underlying age-related differences in motor processing speed.iScience · 2023Article
- Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans.Scientific reports · 2022Article
- Article
- Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine.Journal of proteome research · 2021Article
- COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021Article
- The neurobiology of wellness:NeuroImage · 2021Article
- Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma.BioMed research international · 2021Article
- Glutamine/glutamate (Glx) concentration in prefrontal cortex predicts reversal learning performance in the marmoset.Behavioural brain research · 2018Article
- Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels.Journal of autism and developmental disorders · 2018Article
- Frontal lobe metabolic alterations in autism spectrum disorder: aNeuropsychiatric disease and treatment · 2018Article
- Brain Structural Networks Associated with Intelligence and Visuomotor Ability.Scientific reports · 2017Article
- Biochemistry of the cingulate cortex in autism: An MR spectroscopy study.Autism research : official journal of the International Society for Autism Research · 2016Article
- Proton Magnetic Resonance Spectroscopy: Relevance of Glutamate and GABA to Neuropsychology.Neuropsychology review · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProton Magnetic Resonance Spectroscopy ((1)H-MRS) is a non-invasive imaging technique that enables quantification of neurochemistry in vivo and thereby facilitates investigation of the biochemical underpinnings of human cognitive variability. Studies in the field of cognitive spectroscopy have commonly focused on relationships between measures of N-acetyl aspartate (NAA), a surrogate marker of neuronal health and function, and broad measures of cognitive performance, such as IQ. METHODOLOGY/PRINCIPAL
findingsIn this study, we used (1)H-MRS to interrogate single-voxels in occipitoparietal and frontal cortex, in parallel with assessments of psychometric intelligence, in a sample of 40 healthy adult participants. We found correlations between NAA and IQ that were within the range reported in previous studies. However, the magnitude of these effects was significantly modulated by the stringency of data screening and the extent to which outlying values contributed to statistical analyses. CONCLUSIONS/SIGNIFICANCE: (1)H-MRS offers a sensitive tool for assessing neurochemistry non-invasively, yet the relationships between brain metabolites and broad aspects of human behavior such as IQ are subtle. We highlight the need to develop an increasingly rigorous analytical and interpretive framework for collecting and reporting data obtained from cognitive spectroscopy studies of this kind.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.