ReviewFrontiers in behavioral neuroscience2014
Timing matters: using optogenetics to chronically manipulate neural circuitry and rhythms.
Review in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The ventral hippocampus to paraventricular thalamus circuit regulates context-dependent hyperlocomotion through PAC1 receptor signaling in the chronic stress-induced PTSD mouse model.Translational psychiatry · 2026Article
- Article
- In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits.Nature nanotechnology · 2024Article
- Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism.Translational psychiatry · 2023Article
- Pushing the Frontiers: Optogenetics for Illuminating the Neural Pathophysiology of Bipolar Disorder.International journal of biological sciences · 2023Review
- Restoring circadian gene profiles in clock networks using synthetic feedback control.NPJ systems biology and applications · 2022Article
- Neuronal correlates of depression.Cellular and molecular life sciences : CMLS · 2015Review
- Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline.Oncotarget · 2015Review
- Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine.Translational psychiatry · 2015Article
- Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress.Biological psychiatry · 2015Article
- Shining light on motivation, emotion, and memory processes.Frontiers in behavioral neuroscience · 2015Article
- Retino-hypothalamic regulation of light-induced murine sleep.Frontiers in systems neuroscience · 2014Review
- Grand challenges in cellular biochemistry: the "next-gen" biochemistry.Frontiers in chemistry · 2014Article
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Authors and funding
2 authors.
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Abstract
The ability to probe defined neural circuits with both the spatial and temporal resolution imparted by optogenetics has transformed the field of neuroscience. Although much attention has been paid to the advantages of manipulating neural activity at millisecond timescales in order to elicit time-locked neural responses, little consideration has been given to the manipulation of circuit activity at physiologically relevant times of day, across multiple days. Nearly all biological events are governed by the circadian clock and exhibit 24 h rhythms in activity. Indeed, neural circuit activity itself exhibits a daily rhythm with distinct temporal peaks in activity occurring at specific times of the day. Therefore, experimentally probing circuit function within and across physiologically relevant time windows (minutes to hours) in behaving animals is fundamental to understanding the function of any one particular circuit within the intact brain. Furthermore, understanding how circuit function changes with repeated manipulation is important for modeling the circuit-wide disruptions that occur with chronic disease states. Here, we review recent advances in optogenetic technology that allow for chronic, temporally specific, control of circuit activity and provide examples of chronic optogenetic paradigms that have been utilized in the search for the neural circuit basis of behaviors relevant to human neuropsychiatric disease.
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