Evidence map›Paper›PMID 24592204›Full record

ArticleFrontiers in neuroscience2014

TMS affects moral judgment, showing the role of DLPFC and TPJ in cognitive and emotional processing.

Danique Jeurissen, Alexander T Sack, Alard Roebroeck, Brian E Russ, Alvaro Pascual-Leone

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07635940 (Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture in Psychopathy), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07635940 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture in Psychopathy

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2030Enrolled60ConditionsPsychopathyArmscontinuous theta burst stimulation (cTBS), Intermittent theta burst stimulation (iTBS), Sham
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 88 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Resting-State Neural Signatures of Moral Injury: Associations With Rumination.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Combinatorial approaches for treating neuropsychiatric social impairment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Moral Judgment: An Overlooked Deficient Domain in Multiple Sclerosis?Behavioral sciences (Basel, Switzerland) · 2018
    Review
  16. Article
  17. Article
  18. Article
  19. [Research on the effects of the continuous theta-burst transcranial magnetic stimuli on brain network in emotional processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Danique JeurissenBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA, USA ; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University Maastricht, Netherlands ; Department of Vision and Cognition, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences Amsterdam, Netherlands.
Alexander T SackDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University Maastricht, Netherlands ; Maastricht Brain Imaging Center Maastricht, Netherlands.
Alard RoebroeckDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University Maastricht, Netherlands ; Maastricht Brain Imaging Center Maastricht, Netherlands.
Brian E RussDepartment of Psychology, Harvard University Cambridge, MA, USA.
Alvaro Pascual-LeoneBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA, USA.
Maastricht University · NLBeth Israel Deaconess Medical Center · USHarvard University · USNetherlands Institute for Neuroscience · NL

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
NCRR NIH HHS UL1 RR025758
6 · The paper itself

Abstract

Decision-making involves a complex interplay of emotional responses and reasoning processes. In this study, we use TMS to explore the neurobiological substrates of moral decisions in humans. To examining the effects of TMS on the outcome of a moral-decision, we compare the decision outcome of moral-personal and moral-impersonal dilemmas to each other and examine the differential effects of applying TMS over the right DLPFC or right TPJ. In this comparison, we find that the TMS-induced disruption of the DLPFC during the decision process, affects the outcome of the moral-personal judgment, while TMS-induced disruption of TPJ affects only moral-impersonal conditions. In other words, we find a double-dissociation between DLPFC and TPJ in the outcome of a moral decision. Furthermore, we find that TMS-induced disruption of the DLPFC during non-moral, moral-impersonal, and moral-personal decisions lead to lower ratings of regret about the decision. Our results are in line with the dual-process theory and suggest a role for both the emotional response and cognitive reasoning process in moral judgment. Both the emotional and cognitive processes were shown to be involved in the decision outcome.

Indexed as

decision-makingemotion and reasonmoralityTMS

Identifiers

PMID24592204
PMCPMC3923146
OpenAlexW2137510927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.