ArticleProceedings of the National Academy of Sciences of the United States of America2014
Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 410 papers.
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410 citing papers in PubMed, 809 citations in OpenAlex.
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- CaNAC61, CaNAC79, and CaNAC92 Act as Negative Regulators in Pepper Defense Response AgainstBiology · 2026Article
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- Copper-sensitive OsSPL9 TF regulates expression of indica rice domestication-associated miRNAs and phenotypes.Communications biology · 2026Article
- Dual functions of apigenin in suppressing Phytophthora capsici and shaping the pepper microbiome.Microbiome · 2026Article
- Comparative centromere genomics reveals evolutionary divergence in Solanaceae genomes.Genome biology · 2026Article
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- Analysis of the TGA gene family and the role of SlTGA03 in tomato resistance to Meloidogyne enterolobii.BMC genomics · 2026Article
- A comparative study on the nutrient and organic acid profiles of selected pepper genotypes.Scientific reports · 2026Article
- Rapid Identification of Candidate SNPs and QTLs forCurrent issues in molecular biology · 2026Article
- PGDD 2.0: Plant Genome Duplication Database with updated content and tools.Nucleic acids research · 2026Article
- Quantitative trait loci and genome-wide association study identifies novel loci for plant height in pepper (Frontiers in plant science · 2026Article
- Mechanistic Perspectives From Genomics and Pangenomics of Medicinal and Aromatic Plants: Linking Genome Architecture to Phytochemical Diversity.International journal of genomics · 2026Review
350 more citing papers are in PubMed but not listed here.
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73 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As an economic crop, pepper satisfies people's spicy taste and has medicinal uses worldwide. To gain a better understanding of Capsicum evolution, domestication, and specialization, we present here the genome sequence of the cultivated pepper Zunla-1 (C. annuum L.) and its wild progenitor Chiltepin (C. annuum var. glabriusculum). We estimate that the pepper genome expanded ∼0.3 Mya (with respect to the genome of other Solanaceae) by a rapid amplification of retrotransposons elements, resulting in a genome comprised of ∼81% repetitive sequences. Approximately 79% of 3.48-Gb scaffolds containing 34,476 protein-coding genes were anchored to chromosomes by a high-density genetic map. Comparison of cultivated and wild pepper genomes with 20 resequencing accessions revealed molecular footprints of artificial selection, providing us with a list of candidate domestication genes. We also found that dosage compensation effect of tandem duplication genes probably contributed to the pungent diversification in pepper. The Capsicum reference genome provides crucial information for the study of not only the evolution of the pepper genome but also, the Solanaceae family, and it will facilitate the establishment of more effective pepper breeding programs.
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