ArticleProceedings of the National Academy of Sciences of the United States of America2014
Memory loss in a nonnavigational spatial task after hippocampal inactivation in monkeys.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Is memory spared in monkeys with selective lesions of the hippocampus?Behavioral neuroscience · 2026Article
- Epicranial electrical stimulation improves non-navigational spatial memory in macaque monkeys.Neuroimage. Reports · 2026Article
- Kynurenic Acid Synthesis from D-Kynurenine in the Cerebellum: A Distinct Role of D-Amino Acid Oxidase.Cells · 2025Article
- Sustained Hippocampal Theta Oscillations Reflect Experience-Dependent Learning in Backward Temporal Order Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Focal pharmacological manipulation of serotonin signaling in the amygdala does not alter social behavior.Psychopharmacology · 2025Article
- Hippocampal lesions impair non-navigational spatial memory in macaques.Hippocampus · 2024Article
- Pharmacological Inhibition of the Nucleus Accumbens Increases Dyadic Social Interaction in Macaques.eNeuro · 2024Article
- Quinpirole, but not muscimol, infused into the nucleus accumbens disrupts prepulse inhibition of the acoustic startle in rhesus macaques.Neuropharmacology · 2023Article
- Pharmacological Inactivation of the Bed Nucleus of the Stria Terminalis Increases Affiliative Social Behavior in Rhesus Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques.Behavioral neuroscience · 2021Article
- The Parahippocampal Cortex and its Functional Connection with the Hippocampus are Critical for Nonnavigational Spatial Memory in Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Acupuncture accelerates neural regeneration and synaptophysin production after neural stem cells transplantation in mice.World journal of stem cells · 2020Article
- Dysregulation of behavioral and autonomic responses to emotional and social stimuli following bidirectional pharmacological manipulation of the basolateral amygdala in macaques.Neuropharmacology · 2020Article
- Inhibition of the Deep and Intermediate Layers of the Superior Colliculus Disrupts Sensorimotor Gating in Monkeys.Frontiers in behavioral neuroscience · 2020Article
- Nonnavigational spatial memory performance is unaffected by hippocampal damage in monkeys.Hippocampus · 2019Article
- Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys.Scientific reports · 2018Article
- Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques.eLife · 2018Article
- Spatial Responses, Immediate Experience, and Memory in the Monkey Hippocampus.Current opinion in behavioral sciences · 2017Article
- Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction.Behavioral neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The hippocampus has a well-documented role for spatial navigation across species, but its role for spatial memory in nonnavigational tasks is uncertain. In particular, when monkeys are tested in tasks that do not require navigation, spatial memory seems unaffected by lesions of the hippocampus. However, the interpretation of these results is compromised by long-term compensatory adaptation occurring in the days and weeks after lesions. To test the hypothesis that hippocampus is necessary for nonnavigational spatial memory, we selected a technique that avoids long-term compensatory adaptation. We transiently disrupted hippocampal function acutely at the time of testing by microinfusion of the glutamate receptor antagonist kynurenate. Animals were tested on a self-ordered spatial memory task, the Hamilton Search Task. In the task, animals are presented with an array of eight boxes, each containing a food reinforcer; one box may be opened per trial, with trials separated by a delay. Only the spatial location of the boxes serves as a cue to solve the task. The optimal strategy is to open each box once without returning to previously visited locations. Transient inactivation of hippocampus reduced performance to chance levels in a delay-dependent manner. In contrast, no deficits were seen when boxes were marked with nonspatial cues (color). These results clearly document a role for hippocampus in nonnavigational spatial memory in macaques and demonstrate the efficacy of pharmacological inactivation of this structure in this species. Our data bring the role of the hippocampus in monkeys into alignment with the broader framework of hippocampal function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.