ArticleProceedings of the National Academy of Sciences of the United States of America2014
Transcriptional divergence and conservation of human and mouse erythropoiesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 87 citations in OpenAlex.
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- Global comprehensive transcriptomic and proteomic analyses of murine terminal erythroid differentiation.Global medical genetics · 2025Article
- Understanding erythroid physiology and pathology in humanized mice: A closer look.British journal of haematology · 2025Review
- Case Report: Identification and functional characterization of a novel heterozygous splice-donor (c.647+1G>A) site mutation in theFrontiers in genetics · 2025Article
- Erythropoiesis: insights from a genomic perspective.Experimental & molecular medicine · 2024Review
- Terminal deoxynucleotidyl transferase and CD84 identify human multi-potent lymphoid progenitors.Nature communications · 2024Article
- The genesis of human hematopoietic stem cells.Blood · 2023Article
- scChIX-seq infers dynamic relationships between histone modifications in single cells.Nature biotechnology · 2023Article
- Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation.iScience · 2023Article
- E-Cadherin Expression Distinguishes Mouse from Human Hematopoiesis in the Basophil and Erythroid Lineages.Biomolecules · 2022Article
- YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation.Stem cell research & therapy · 2022Article
- Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34Scientific reports · 2021Article
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- Generation of an immortalised erythroid cell line from haematopoietic stem cells of a haemoglobin E/β-thalassemia patient.Scientific reports · 2020Article
- Overexpression of miR-669m inhibits erythroblast differentiation.Scientific reports · 2020Article
- An Overview of Different Strategies to Recreate the Physiological Environment in Experimental Erythropoiesis.International journal of molecular sciences · 2020Review
- Comparative transcriptomics of primary cells in vertebrates.Genome research · 2020Article
1 more citing papers are in PubMed but not listed here.
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6 authors at 3 institutions in 1 country.
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Abstract
Mouse models have been used extensively for decades and have been instrumental in improving our understanding of mammalian erythropoiesis. Nonetheless, there are several examples of variation between human and mouse erythropoiesis. We performed a comparative global gene expression study using data from morphologically identical stage-matched sorted populations of human and mouse erythroid precursors from early to late erythroblasts. Induction and repression of major transcriptional regulators of erythropoiesis, as well as major erythroid-important proteins, are largely conserved between the species. In contrast, at a global level we identified a significant extent of divergence between the species, both at comparable stages and in the transitions between stages, especially for the 500 most highly expressed genes during development. This suggests that the response of multiple developmentally regulated genes to key erythroid transcriptional regulators represents an important modification that has occurred in the course of erythroid evolution. In developing a systematic framework to understand and study conservation and divergence between human and mouse erythropoiesis, we show how mouse models can fail to mimic specific human diseases and provide predictions for translating findings from mouse models to potential therapies for human disease.
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