Evidence map›Paper›PMID 24591522›Full record

ReviewCold Spring Harbor perspectives in biology2014

Regulation of the X chromosomes in Caenorhabditis elegans.

Susan Strome, William G Kelly, Sevinc Ercan, Jason D Lieb

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. eIF4E assembly intobioRxiv : the preprint server for biology · 2025
    Article
  7. Conservative evolution of genetic and genomic features inbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. High-resolution reconstruction of aRNA (New York, N.Y.) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. RNA stability controlled by mNature structural & molecular biology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susan StromeDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064.
William G Kelly
Sevinc Ercan
Jason D Lieb

Funding

Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7M
IMMUNOLOGIC STUDY OF GERM GRANULES IN C. ELEGANS EMBRY0SR01GM034059 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1985 to 2020
$8.9M
Mechanisms of X chromosome dosage compensation in C. elegansR01GM107293 · NIGMS · NEW YORK UNIVERSITY · PI ERCAN, SEVINC · 2014 to 2018
$1.5M
NCI NIH HHS T32 CA009156NIGMS NIH HHS R01 GM034059NIGMS NIH HHS R01 GM107293
6 · The paper itself

Abstract

Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.

Indexed as

Dosage Compensation, GeneticX ChromosomeAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFemaleGene Expression RegulationHistonesMaleModels, GeneticSex Determination ProcessesX Chromosome InactivationCaenorhabditis elegans ProteinsHistones

Identifiers

PMID24591522
PMCPMC3942922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.