ReviewCold Spring Harbor perspectives in biology2014
The pre-endosymbiont hypothesis: a new perspective on the origin and evolution of mitochondria.
Review in Cold Spring Harbor perspectives in biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 75 citations in OpenAlex.
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Mitochondrial Genome Reduction and Accelerated Evolution in Planktonic Foraminiferans.MicrobiologyOpen · 2026Article
- Review
- Gatekeepers of the Germ Line: How Mitochondria Shape Reproductive Evolution in Metazoans.Biology · 2025Review
- Eukaryogenesis From FECA to LECA: Radical Steps Along the Way.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Mitochondrial diseases: from molecular mechanisms to therapeutic advances.Signal transduction and targeted therapy · 2025Review
- Chapter 5: Major Biological Innovations in the History of Life on Earth.Astrobiology · 2024Article
- Enhancement of Mitochondrial Homeostasis: A Novel Approach to Attenuate Hypoxic Myocardial Injury.International journal of medical sciences · 2024Review
- Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges.Mitochondrion · 2022Article
- Hydrogenosome, Pairing Anaerobic Fungi and HJournal of fungi (Basel, Switzerland) · 2022Review
- Switching a conflicted bacterial DTD-tRNA code is essential for the emergence of mitochondria.Science advances · 2022Article
- Are Cyanobacteria an Ancestor of Chloroplasts or Just One of the Gene Donors for Plants and Algae?Genes · 2021Article
- Gene Duplications Trace Mitochondria to the Onset of Eukaryote Complexity.Genome biology and evolution · 2021Article
- Division of labour in a matrix, rather than phagocytosis or endosymbiosis, as a route for the origin of eukaryotic cells.Biology direct · 2020Article
- Complex origins of chloroplast membranes with photosynthetic machineries: multiple transfers of genes from divergent organisms at different times or a single endosymbiotic event?Journal of plant research · 2020Article
- Article
- The Mitogenome of Norway Spruce and a Reappraisal of Mitochondrial Recombination in Plants.Genome biology and evolution · 2020Article
- Structural Patching Fosters Divergence of Mitochondrial Ribosomes.Molecular biology and evolution · 2019Article
- Relative timing of mitochondrial endosymbiosis and the "pre-mitochondrial symbioses" hypothesis.IUBMB life · 2018Review
- Heat shock transcriptional factor mediates mitochondrial unfolded protein response.Current genetics · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial DNA (mtDNA) is unquestionably the remnant of an α-proteobacterial genome, yet only ~10%-20% of mitochondrial proteins are demonstrably α-proteobacterial in origin (the "α-proteobacterial component," or APC). The evolutionary ancestry of the non-α-proteobacterial component (NPC) is obscure and not adequately accounted for in current models of mitochondrial origin. I propose that in the host cell that accommodated an α-proteobacterial endosymbiont, much of the NPC was already present, in the form of a membrane-bound metabolic organelle (the premitochondrion) that compartmentalized many of the non-energy-generating functions of the contemporary mitochondrion. I suggest that this organelle also possessed a protein import system and various ion and small-molecule transporters. In such a scenario, an α-proteobacterial endosymbiont could have been converted relatively directly and rapidly into an energy-generating organelle that incorporated the extant metabolic functions of the premitochondrion. This model (the "pre-endosymbiont hypothesis") effectively represents a synthesis of previous, contending mitochondrial origin hypotheses, with the bulk of the mitochondrial proteome (much of the NPC) having an endogenous origin and the minority component (the APC) having a xenogenous origin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.